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Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
TLDR
It is found that rs401681[C] on chromosome 5p15 satisfied the threshold for genome-wide significance and seems to confer protection against cutaneous melanoma, and investigation of the region led to rs2736098[A], which showed stronger association with some cancer types, but neither variant could fully account for the association of the other. Expand
Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy.
TLDR
Determination of CAix expression in nephrectomy specimens of RCC patients improves prognostic accuracy; high CAIX expression appears to correlate with a favourable prognosis and a greater likelihood of response to systemic treatment for metastatic disease. Expand
Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
Renal cell carcinoma of the clear cell type (ccRCC) is associated with loss of functional von Hippel-Lindau (VHL) protein and high, homogeneous expression of the G250MN protein, an isoenzyme of theExpand
Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity.
TLDR
In-patient proof is provided that the observed "on-target" toxicity is antigen-directed and can be prevented by blocking antigenic sites in off-tumor organs and allowing higher T cell doses. Expand
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
TLDR
A two-stage genome-wide association study of renal cell carcinoma in 3,772 affected individuals and 8,505 controls of European background and followed up 6 SNPs in 3 replication studies reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights. Expand
Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells.
TLDR
It is documented the novel feature that therapeutic cells, which were ex vivo engineered by means of transduction with a minimal γ-retroviral vector, do express immunogenic vector-encoded epitopes, which might compromise persistence of these cells. Expand
Aminopeptidase A is a functional target in angiogenic blood vessels.
We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain mechanistic insight, we evaluated angiogenesisExpand
Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
TLDR
Of the markers considered in this study, CA IX expression status was the most reliable hypoxia marker for predicting tumor aggressiveness and was associated with shorter disease free survival in univariate analysis and multivariate analysis. Expand
Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250.
TLDR
Since tumor-sterilizing levels may be guided to the tumor when high doses 131I-cG250 are administered and cG250 appears to be immunosilent, cG 250 is a promising vehicle for radioimmunotherapy in RCC. Expand
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