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Identification of the osteoprotegerin/receptor activator of nuclear factor-kappa B ligand system in gingival crevicular fluid and tissue of patients with chronic periodontitis.
The findings imply that in this cross-sectional study of GCF, RANKL, IL-6 and OSM were all prominent in periodontitis sites, whereas OPG was inconsistently found in a few samples of diseased sites but was undetectable in any of the control sites. Expand
Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients.
The results of this study show for the first time that overexpression of the HDAC protein is a frequent event in oral cancer and could be used as a prognostic factor in oral SCC. Expand
Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells.
In head and neck squamous cell carcinoma (HNSCC), CTGF promotes the MET and reduces invasiveness and it is found that CTGF enhances the stem-like properties of HNSCC cells and increases the expression of multiple pluripotency genes. Expand
Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells.
The results indicate that esculetin enhances TRAIL-induced apoptosis primarily through upregulation of DR5, which may be a novel treatment strategy for oral cancers. Expand
Highly efficient release of lovastatin from poly(lactic‐co‐glycolic acid) nanoparticles enhances bone repair in rats
The results suggest the new lovastatin‐releasing PLGA delivery device exhibits potential for clinical treatment of bony defects, as well as optimization of the emulsion technique in the fabrication process for PLGA nanoparticles. Expand
MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma.
OBJECTIVES Oral squamous cell carcinoma (OSCC) accounts for>90% oral cancer which is a leading cause of cancer death worldwide. Early diagnosis may well offer an opportunity to increase survival toExpand
Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan.
The expression of HIF-1 alpha is an early event in oral carcinogenesis and can predict the progression of OSCCs and the survival ofOSCC patients. Expand
Survivin expression predicts poorer prognosis in patients with areca quid chewing-related oral squamous cell carcinoma in Taiwan.
Results indicate that survivinprotein expression may be an important early event in oral carcinogenesis and predicts unfavorable prognosis for oral SCC, and suggests that modulation of survivin protein expression may provide a novel strategy for the therapy of Oral SCC. Expand
HDAC2 promotes cell migration/invasion abilities through HIF-1α stabilization in human oral squamous cell carcinoma.
It is demonstrated that HDAC2 maintains HIF-1α stability, probably at the level of protein modification, which in turn leads to the increase in cell invasion/migration ability in oral cancer progression. Expand
MicroRNA-29b regulates migration in oral squamous cell carcinoma and its clinical significance.
MiR-29b acts as an oncomir, promoting cell migration through CX3CL1 suppression, and could be a potential therapeutic target for preventing OSCC progression. Expand