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MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma
TLDR
Germline mutations in MAX are responsible for 1.12% of PCC/PGL in patients without evidence of other known mutations and should be considered in the genetic work-up of these patients.
Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number
TLDR
Findings suggest an involvement of FAK in the onset and progression of HNSCC and provide an insight into a mechanism ofFAK activation alternative to gene amplification.
A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins.
TLDR
In vitro selection of binding sites shows that the optimal targets for the cut repeat II contain one or more CCAAT boxes and, like the homeo domain, an ATTA core, indicating that the DNA-binding activity of the second cut repeat can account for the suggested role of CDP mClox as C CAAT displacement protein, a putative repressor of gene expression.
A two-step mechanism for 5' and 3' splice-site pairing
TLDR
It is reported here that 5' and 3' splice sites located on separate synthetic pre-mRNA substrates can be efficiently trans-spliced if the 3' trans- Splicing substrate contains these downstream sequence elements.
Identification of proteins that interact with exon sequences, splice sites, and the branchpoint sequence during each stage of spliceosome assembly
TLDR
The observation that these proteins are specifically associated with critical pre-mRNA sequence elements in functional complexes at different stages of spliceosome assembly implicates roles for these factors in key recognition events during the splicing pathway.
Identification and Functional Characterization of a K+ Channel α-Subunit with Regulatory Properties Specific to Brain
TLDR
A new K+ channel α-subunit (Kv2.3r) is cloned that is unable to form functional channels on its own but that has a major regulatory function, which might contribute to further increase the functional diversity of K+ channels necessary to specify the intrinsic electrical properties of individual neurons.
Control of long-distance cell-to-cell communication and autophagosome transfer in squamous cell carcinoma via tunneling nanotubes
TLDR
This study demonstrates that TnTs are not specific of epithelial or mesenchymal phenotypes and allow the trafficking of endosomal/lysosomal vesicles, mitochondria, and autophagosomes between both types of cells.
Lung tumorspheres reveal cancer stem cell-like properties and a score with prognostic impact in resected non-small-cell lung cancer
TLDR
The findings provide relevant prognostic information for lung adenocarcinoma patients and the basis for developing novel therapies, and identify suitable markers and targets for lung squamous cell carcinoma patients.
Evidence that U5 snRNP recognizes the 3′ splice site for catalytic step II in mammals
TLDR
It is shown that U2AF65 crosslinking is replaced byCrosslinking of three proteins of 110, 116 and 220 kDa prior to catalytic step II, and evidence that all three proteins are components of U5 snRNP is provided, suggesting that U5SnRNP was positioned on the 3′ splice site by an interaction with U2 snR NP bound at the BPS and by a direct interaction with the pyrimidine tract.
P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases
TLDR
The objective of this study was to investigate the expression pattern and prognostic significance of p53 expression in HNSCC of the same location, treated in the same way, and with long‐term follow‐up.
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