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Butaclamol

Known as: Butaclamol [Chemical/Ingredient] 
A benzocycloheptapyridoisoquinolinol that has been used as an antipsychotic, especially in schizophrenia.
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (2)

AY-23,028isobutaclamol

Broader (2)

Antipsychotic AgentsDopamine Antagonists
Butaclamol HydrochlorideIn Bloodagonistsanalogs & derivatives

Papers overview

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1985
1985
The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors.
The pKa values for butaclamol (1), 1,2,3,5,6,10b beta-hexahydro-6 alpha-phenylpyrrolo[2,1-alpha]isoquinoline (2, McN-4612-Y), and… 
1984
1984
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.
The semirigid 7-phenylquinolizidine system was selected for the design of new potential antipsychotic agents because it fulfills… 
1981
1981
Stereospecific Antagonism by d-Butaclamol of Dopamine‐Induced Relaxation of the Isolated Rabbit Mesenteric Artery
Summary We characterized the properties of vascular dopamine receptors on isolated rabbit mesenteric arteries preincubated with… 
1979
1979
Mapping the dopamine receptor. 1. Features derived from modifications in ring E of the neuroleptic butaclamol.
Several analogues of the neuroleptic agent butaclamol, having modifications in the ring E region of the molecule, have been… 
1979
1979
Mapping the dopamine receptor. 2. Features derived from modifications in the rings A/B region of the neuroleptic butaclamol.
Several analogues of the neuroleptic agent butaclamol having modifications in the rings A/B region of the molecule have been… 
1978
1978
Neuroleptics related to butaclamol. An investigation of the effects of chlorine substituents on the aromatic rings.
The synthesis of analogues of the antipsychotic drug butaclamol bearing chloro substituents on the benzene rings is described. On… 
1978
1978
Effect of haloperidol and apomorphine treatment on dopamine receptors in pituitary and striatum.
Prompted by an interest in the similarity of brain and tuberoinfundibular systems, the authors studied butaclamol-specific… 
1978
1978
Neuroleptics related to butaclamol. Synthesis and some psychopharmacological effects of a series of 3-aryl analogues.
The synthesis and some pharmacological effects of 16 3-aryl analogues of butaclamol, a new antipsychotic drug, are described. The… 
1978
1978
The effect of blockade of dopamine receptors on the inhibition of episodic luteinizing hormone release during electrical stimulation of the arcuate nucleus in ovariectomized rats.
This study examined the possible involvement of dopamine (DA) in mediating the inhibition of episodic LH release that occurs… 
1976
1976
Effect of structural analogs of butaclamol (a new antipsychotic drug) on striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats.
The 3-isopropyl (I), 3-cyclohexyl (II) and 3-phenyl (III) analogs of the new antipsychotic drug butaclamol, which contains a 3…