Share This Author
Dopamine Receptor Signaling
- K. Neve, J. Seamans, H. Trantham-Davidson
- BiologyJournal of receptor and signal transduction…
- 1 January 2004
The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences…
Modulation of D2R-NR2B Interactions in Response to Cocaine
Cloning and expression of a rat D2 dopamine receptor cDNA
This receptor has been characterized on the basis of three criteria: the deduced amino-acid sequence which reveals that it is a member of the family of G-protein-coupled receptors; the tissue distribution of the mRNA which parallels that of the D2 dopamine receptor; and the pharmacological profile of mouse fibroblast cells transfected with the cDNA.
Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization
FRET and bioluminescence resonance energy transfer techniques were used to confirm the occurrence of A2AR-D2R interactions in co-transfected cells and suggest that the helix 5-I3-helix 6-E3 portion of D2R holds the site(s) for interaction with A2 AR.
Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type.
- A. Eshleman, M. Carmolli, M. Cumbay, C. Martens, K. Neve, A. Janowsky
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 May 1999
The present results indicate that the cocaine analog [125I]RTI-55 has unique binding properties at each of the transporters and that the use of recombinant transportters expressed by a single cell type can provide a powerful screening tool for drugs interacting with biogenic amine transporter, such as possible cocaine antagonists.
The Dopamine Receptors
- K. Neve
- BiologyThe Receptors
The Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models Gerard J. Jocoy and Michael S. Levine Unraveling the Role of Dopamines Receptor in vivo: Lessons from Knockout Mice.
Regulation of dopamine D2 receptors by sodium and pH.
- K. Neve
- Biology, ChemistryMolecular pharmacology
- 1 April 1991
Data suggest that the conformation of D2 receptors is regulated by both Na+ and H+, which may be a reflection of the ability of D 2 receptors to modulate Na+/H+ exchange.
Dopamine D2 receptor stimulation of mitogen‐activated protein kinases mediated by cell type‐dependent transactivation of receptor tyrosine kinases
- Chunhe Wang, D. Buck, Rui-rui Yang, T. Macey, K. Neve
- Biology, ChemistryJournal of neurochemistry
- 1 May 2005
D2 receptor agonist quinpirole enhanced the coprecipitation of D2 and EGF receptors in NS20Y cells, suggesting that D2 receptor activation induced the formation of a macromolecular signaling complex that includes both receptors.
Sensitization of adenylate cyclase by Galpha i/o-coupled receptors.
Heterologous sensitization of cyclic AMP signaling likely represents a cellular adaptive response, a mechanism by which the cell compensates for chronic inhibitory input and the potential role of sensitization in neuronal function is described.