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CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
CONTEXT Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI),Expand
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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
IMPORTANCE Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in personsExpand
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An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons.
Neuroscience, including research on Alzheimer's disease, is hampered by the lack of suitable in vitro models to study the human nervous system. To counteract this, many attempts to differentiate cellExpand
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CSF-Biomarkers in Olympic Boxing: Diagnosis and Effects of Repetitive Head Trauma
Background Sports-related head trauma is common but still there is no established laboratory test used in the diagnostics of minimal or mild traumatic brain injuries. Further the effects of recurrentExpand
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Improved client participation in the rehabilitation process using a client-centred goal formulation structure.
The aim was to evaluate whether the use of a client-centred instrument, the Canadian Occupational Performance Measure (COPM), affects the patients' perception of active participation in theExpand
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Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.
BACKGROUND Tau protein and the 42-amino acid form of beta-amyloid (Abeta42) measured in cerebrospinal fluid (CSF) have been proposed as potential biochemical diagnostic markers for Alzheimer disease.Expand
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Dementia in primary care: why the low detection rate?
OBJECTIVE The aim of the present study was to find reasons for the low detection rate of dementia in primary care. Another aim was to investigate the attitudes and knowledge on dementia among SwedishExpand
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Cerebrospinal Fluid Phospho-Tau, Total Tau and β-Amyloid1–42 in the Differentiation between Alzheimer’s Disease and Vascular Dementia
The two most frequently examined biomarkers in the diagnosis of dementia are cerebrospinal fluid (CSF) tau and β-amyloid1–42 (Aβ1–42). An assay for tau phosphorylated at threonine 181 (phospho-tau)Expand
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High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue
[3H]Paroxetine binding to human brain tissue was characterized. Competition studies in the putamen and frontal cortex revealed single-site binding models for binding sensitive to 5-hydroxytryptamineExpand
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Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma
Objectives: The aim of this study was to investigate if olympic (amateur) boxing is associated with elevation of brain injury biomarkers in peripheral blood compared to controls. Materials andExpand
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