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Bleomycin

Known as: Bleomicina, Bleomycins, Bleomycin Antibiotic 
A basic glycopeptide antineoplastic antibiotic isolated from Streptomyces verticillus. Bleomycin antibiotics form complexes with iron that react with… 
National Institutes of Health

Related topics

Related topics

47 relations

Narrower (21)

BCD protocolBLEDTABLEO-cellBleomycin A2
BOMP protocolBleomycin SulfateBleomycin/Methotrexate/VinblastineBleomycin/Prednisone/Vincristine regimen (BOP)

Broader (1)

Glycopeptides

Papers overview

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2003
2003
Transforming Growth Factor-1 Decreases Expression of the Epithelial Sodium Channel ENaC and Alveolar Epithelial Vectorial Sodium and Fluid Transport via an ERK 1 / 2-dependent Mechanism *
  • 2003
  • Corpus ID: 30919977
From the §Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia… 
Highly Cited
1985
Highly Cited
1985
Host-mediated therapeutic effects produced by appropriately timed administration of bleomycin on a rat fibrosarcoma.
The timing of bleomycin (BLM) administration after KMT-17 tumor inoculation was found to be important for optimizing its… 
Highly Cited
1982
Highly Cited
1982
Hyperoxia, but not thoracic X-irradiation, potentiates bleomycin- and cyclophosphamide-induced lung damage in mice.
The intraperitoneal administration of cyclophosphamide or bleomycin to BALB/c mice resulted in lung cell damage followed by… 
Highly Cited
1981
Highly Cited
1981
An active intermediate formed in the reaction of bleomycin-Fe(II) complex with oxygen.
The base-release activity of oxygen adduct of bleomycin-Fe(II) complex [BLM-Fe(II)] from DNA decreased with a half-life of 5.2… 
1981
1981
Prospective study of the pulmonary toxicity of continuously infused bleomycin.
: Bleomycin is an effective antitumor drug but must be used cautiously because of its pulmonary toxicity. We performed a… 
Highly Cited
1979
Highly Cited
1979
BLEDTA: tumor localization by a bleomycin analogue containing a metal-chelating group.
Two different Co(III) complexes of the antitumor antibiotic bleomycin have been prepared, and their in vivo distribution in mice… 
Highly Cited
1975
Highly Cited
1975
Binding of bleomycin to DNA in bleomycin-sensitive and -resistant rat ascites hepatoma cells.
The 14C activity of [14C]bleomycin bound to DNA in bleomycin-sensitive rat ascites hepatoma cells (AH-66) was 8.7 times higher… 
Highly Cited
1975
Highly Cited
1975
Combination Chemotherapy with cis-Diamminedichloroplatinum (II) and Bleomycin in Tumors of the Head and Neck
28 patients with head and neck tumors not suitable for definitive treatment with radiation or surgery were treated with cis… 
Highly Cited
1970
Highly Cited
1970
Lethal effect of bleomycin on cultured mammalian cells.
By using cultured mammalian cells lethal effect of bleomycin was measured in terms of mean lethal dose (D37) ; the cytotoxicity… 
1968
1968
The distribution of 3H-bleomycin in mouse tissue.
A bleomycin mixture which contained A2 as the main component and B2 as the second component was tritiated. The 3H-bleomycin thus…