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Bleomycin A2
Known as:
Bleomycin A(2)
, N1-(3-(Dimethylsulfonio)propyl)bleomycinamide
, Pingyangmycin A2
The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated…
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National Institutes of Health
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2 relations
Broader (1)
Bleomycin
zhengguangmycin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Genome mining for novel natural product discovery.
G. Challis
Journal of Medicinal Chemistry
2008
Corpus ID: 207234756
Genomics has resulted in the deposition of a huge quantity of DNA sequence data from a wide variety of organisms in publicly…
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Highly Cited
1985
Highly Cited
1985
Interaction of bleomycin A2 with deoxyribonucleic acid: DNA unwinding and inhibition of bleomycin-induced DNA breakage by cationic thiazole amides related to bleomycin A2.
L. Fisher
,
R. Kuroda
,
T. Sakai
Biochemistry
1985
Corpus ID: 10140897
The association of the antitumor antibiotic bleomycin A2 with DNA has been investigated by employing several 2-substituted…
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Highly Cited
1984
Highly Cited
1984
Characterization of the association of radiolabeled bleomycin A2 with HeLa cells.
S. Roy
,
S. Horwitz
Cancer Research
1984
Corpus ID: 14138372
The association of [3H]bleomycin A2 and Cu(II):[3H]bleomycin A2 with HeLa cells has been characterized. Under the conditions of…
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Highly Cited
1983
Highly Cited
1983
Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity.
J. Lazo
,
C. Humphreys
Proceedings of the National Academy of Sciences…
1983
Corpus ID: 39128708
The biochemical basis for bleomycin-induced pulmonary toxicity was studied in vitro and in vivo with an improved HPLC system. The…
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Highly Cited
1982
Highly Cited
1982
Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage.
M. Trush
,
E. Mimnaugh
,
E. Ginsburg
,
T. E. Gram
Journal of Pharmacology and Experimental…
1982
Corpus ID: 12311674
Bleomycin-dependent DNA chain breakage catalyzed by rat lung microsomes and NADPH was significantly inhibited by the reactive…
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Highly Cited
1982
Highly Cited
1982
Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin.
J. Kross
,
W. D. Henner
,
S. Hecht
,
W. Haseltine
Biochemistry
1982
Corpus ID: 39469088
The sites of cleavage of DNA by bleomycin A2, bleomycin B2, phleomycin, tallysomycin A, and Blenoxane (Bristol-Meyers) in…
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1979
1979
Bleomycin A2: a ferrous oxidase.
W. Caspary
,
C. Niziak
,
D. Lanzo
,
R. Friedman
,
N. Bachur
Molecular Pharmacology
1979
Corpus ID: 34687181
The bleomycins are polypeptides produced by Streptomyces verticullus and are used in chemotherapy of various malignancies. We…
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Highly Cited
1978
Highly Cited
1978
Interaction of bleomycin with DNA.
M. Takeshita
,
A. Grollman
,
E. Ohtsubo
,
H. Ohtsubo
Proceedings of the National Academy of Sciences…
1978
Corpus ID: 41029536
The sequence of oligonucleotides produced by the action of bleomycin and ferrous ion on double- and single-stranded DNA has been…
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Highly Cited
1977
Highly Cited
1977
Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies.
M. Chien
,
A. Grollman
,
S. Horwitz
Biochemistry
1977
Corpus ID: 37729779
The interaction of bleomycin A2 with DNA has been examined by fluorescence spectroscopy and proton magnetic resonance techniques…
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Highly Cited
1968
Highly Cited
1968
Mechanism of action of bleomycin. Studies with the growing culture of bacterial and tumor cells.
H. Suzuki
,
K. Nagai
,
H. Yamaki
,
N. Tanaka
,
H. Umezawa
Journal of antibiotics (Tokyo. )
1968
Corpus ID: 46166749
Bleomycin was observed to inhibit DNA and protein syntheses in intact Escherichia coli, Ehrlich carcinoma and HeLa cells. DNA…
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