Bleomycin A2

Known as: Bleomycin A(2), N1-(3-(Dimethylsulfonio)propyl)bleomycinamide, Pingyangmycin A2 
The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated… (More)
National Institutes of Health

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Bleomycin
zhengguangmycin

Papers overview

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Review
2008
Review
2008
Genome mining for novel natural product discovery.
Genomics has resulted in the deposition of a huge quantity of DNA sequence data from a wide variety of organisms in publicly… (More)
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Review
1999
Review
1999
Bleomycin: Synthetic and Mechanistic Studies.
The subtleties of the structure and function of bleomycin A2 (1), a clinically employed antitumor agent that derives its… (More)
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1984
1984
Characterization of the association of radiolabeled bleomycin A2 with HeLa cells.
The association of [3H]bleomycin A2 and Cu(II):[3H]bleomycin A2 with HeLa cells has been characterized. Under the conditions of… (More)
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1984
1984
Activation of bleomycin A2 to a DNA-damaging intermediate by phorbol ester-stimulated human polymorphonuclear leukocytes.
Metabolically stimulated polymorphonuclear leukocytes (PMNs) generate reactive oxygen metabolites that are capable not only of… (More)
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1983
1983
Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity.
The biochemical basis for bleomycin-induced pulmonary toxicity was studied in vitro and in vivo with an improved HPLC system. The… (More)
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1982
1982
Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage.
Bleomycin-dependent DNA chain breakage catalyzed by rat lung microsomes and NADPH was significantly inhibited by the reactive… (More)
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1981
1981
Chemical synthesis of radiolabeled bleomycin A2 and its binding to DNA.
A method for the preparation of biologically active [3H]- and [13C]bleomycin A2 is described. Demethyl Cu(II):bleomycin A2… (More)
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1979
1979
Control of permeation of bleomycin A2 by polyene antibiotics in cultured Chinese hamster cells.
Control of permeation of bleomycin A2, a well-known antitumor antibiotic, in combination with various polyene macrolide… (More)
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1969
1969
Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of 2-mercaptoethanol.
Decrease of melting temperature (Tm) of Escherichia coli 15T" DNA, with little breakage of the DNA strand, was observed in the… (More)
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1968
1968
Mechanism of action of bleomycin. Studies with the growing culture of bacterial and tumor cells.
Bleomycin was observed to inhibit DNA and protein syntheses in intact Escherichia coli, Ehrlich carcinoma and HeLa cells. DNA… (More)
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