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Bleomycin A2

Known as: Bleomycin A(2), N1-(3-(Dimethylsulfonio)propyl)bleomycinamide, Pingyangmycin A2 
The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated… Expand
National Institutes of Health

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2 relations

Broader (1)

Bleomycin
zhengguangmycin

Papers overview

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Review
2008
Review
2008
Genome mining for novel natural product discovery.
  • G. Challis
  • Journal of medicinal chemistry
  • 2008
    • Corpus ID: 207234756
Genomics has resulted in the deposition of a huge quantity of DNA sequence data from a wide variety of organisms in publicly… Expand
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Highly Cited
1985
Highly Cited
1985
Interaction of bleomycin A2 with deoxyribonucleic acid: DNA unwinding and inhibition of bleomycin-induced DNA breakage by cationic thiazole amides related to bleomycin A2.
The association of the antitumor antibiotic bleomycin A2 with DNA has been investigated by employing several 2-substituted… Expand
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Highly Cited
1983
Highly Cited
1983
Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity.
The biochemical basis for bleomycin-induced pulmonary toxicity was studied in vitro and in vivo with an improved HPLC system. The… Expand
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Highly Cited
1982
Highly Cited
1982
Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage.
Bleomycin-dependent DNA chain breakage catalyzed by rat lung microsomes and NADPH was significantly inhibited by the reactive… Expand
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1979
1979
Bleomycin A2: a ferrous oxidase.
The bleomycins are polypeptides produced by Streptomyces verticullus and are used in chemotherapy of various malignancies. We… Expand
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Highly Cited
1978
Highly Cited
1978
Interaction of bleomycin with DNA.
The sequence of oligonucleotides produced by the action of bleomycin and ferrous ion on double- and single-stranded DNA has been… Expand
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Highly Cited
1978
Highly Cited
1978
A spectroscopic investigation of the metal binding site of bleomycin A2. The Cu(II) and Zn(II) derivatives.
Using a combination of ultraviolet-visible absorption, 1H NMR and ESR techniques we have established that N(1) of the imidazole… Expand
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Highly Cited
1977
Highly Cited
1977
Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies.
The interaction of bleomycin A2 with DNA has been examined by fluorescence spectroscopy and proton magnetic resonance techniques… Expand
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Highly Cited
1969
Highly Cited
1969
Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of 2-mercaptoethanol.
Decrease of melting temperature (Tm) of Escherichia coli 15T- DNA, with little breakage of the DNA strand, was observed in the… Expand
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Highly Cited
1968
Highly Cited
1968
Mechanism of action of bleomycin. Studies with the growing culture of bacterial and tumor cells.
Bleomycin was observed to inhibit DNA and protein syntheses in intact Escherichia coli, Ehrlich carcinoma and HeLa cells. DNA… Expand
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