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Bleomycin A2

Known as: Bleomycin A(2), N1-(3-(Dimethylsulfonio)propyl)bleomycinamide, Pingyangmycin A2 
The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated… 
National Institutes of Health

Papers overview

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Review
2008
Review
2008
  • G. Challis
  • Journal of Medicinal Chemistry
  • 2008
  • Corpus ID: 207234756
Genomics has resulted in the deposition of a huge quantity of DNA sequence data from a wide variety of organisms in publicly… 
Highly Cited
1985
Highly Cited
1985
The association of the antitumor antibiotic bleomycin A2 with DNA has been investigated by employing several 2-substituted… 
Highly Cited
1984
Highly Cited
1984
The association of [3H]bleomycin A2 and Cu(II):[3H]bleomycin A2 with HeLa cells has been characterized. Under the conditions of… 
Highly Cited
1983
Highly Cited
1983
The biochemical basis for bleomycin-induced pulmonary toxicity was studied in vitro and in vivo with an improved HPLC system. The… 
Highly Cited
1982
Highly Cited
1982
Bleomycin-dependent DNA chain breakage catalyzed by rat lung microsomes and NADPH was significantly inhibited by the reactive… 
Highly Cited
1982
Highly Cited
1982
The sites of cleavage of DNA by bleomycin A2, bleomycin B2, phleomycin, tallysomycin A, and Blenoxane (Bristol-Meyers) in… 
1979
1979
The bleomycins are polypeptides produced by Streptomyces verticullus and are used in chemotherapy of various malignancies. We… 
Highly Cited
1978
Highly Cited
1978
The sequence of oligonucleotides produced by the action of bleomycin and ferrous ion on double- and single-stranded DNA has been… 
Highly Cited
1977
Highly Cited
1977
The interaction of bleomycin A2 with DNA has been examined by fluorescence spectroscopy and proton magnetic resonance techniques… 
Highly Cited
1968
Highly Cited
1968
Bleomycin was observed to inhibit DNA and protein syntheses in intact Escherichia coli, Ehrlich carcinoma and HeLa cells. DNA…