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Bleomycin A2

Known as: Bleomycin A(2), N1-(3-(Dimethylsulfonio)propyl)bleomycinamide, Pingyangmycin A2 
The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated… Expand
National Institutes of Health

Papers overview

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Review
2008
Review
2008
  • G. Challis
  • Journal of medicinal chemistry
  • 2008
  • Corpus ID: 207234756
Genomics has resulted in the deposition of a huge quantity of DNA sequence data from a wide variety of organisms in publicly… Expand
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Highly Cited
1985
Highly Cited
1985
The association of the antitumor antibiotic bleomycin A2 with DNA has been investigated by employing several 2-substituted… Expand
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Highly Cited
1983
Highly Cited
1983
The biochemical basis for bleomycin-induced pulmonary toxicity was studied in vitro and in vivo with an improved HPLC system. The… Expand
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Highly Cited
1982
Highly Cited
1982
Bleomycin-dependent DNA chain breakage catalyzed by rat lung microsomes and NADPH was significantly inhibited by the reactive… Expand
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1979
1979
The bleomycins are polypeptides produced by Streptomyces verticullus and are used in chemotherapy of various malignancies. We… Expand
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Highly Cited
1978
Highly Cited
1978
The sequence of oligonucleotides produced by the action of bleomycin and ferrous ion on double- and single-stranded DNA has been… Expand
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Highly Cited
1978
Highly Cited
1978
Using a combination of ultraviolet-visible absorption, 1H NMR and ESR techniques we have established that N(1) of the imidazole… Expand
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Highly Cited
1977
Highly Cited
1977
The interaction of bleomycin A2 with DNA has been examined by fluorescence spectroscopy and proton magnetic resonance techniques… Expand
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Highly Cited
1969
Highly Cited
1969
Decrease of melting temperature (Tm) of Escherichia coli 15T- DNA, with little breakage of the DNA strand, was observed in the… Expand
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Highly Cited
1968
Highly Cited
1968
Bleomycin was observed to inhibit DNA and protein syntheses in intact Escherichia coli, Ehrlich carcinoma and HeLa cells. DNA… Expand
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