Beta-cell Function Measurement

Known as: BCEFNCTN, Beta-cell Function 
The determination of the beta cell function (insulin production and secretion) in a biological specimen.
National Institutes of Health

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Papers overview

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Highly Cited
2009
Highly Cited
2009
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
BACKGROUND The immunopathogenesis of type 1 diabetes mellitus is associated with T-lymphocyte autoimmunity. However, there is… (More)
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Highly Cited
2008
Highly Cited
2008
Pancreatic beta-cell mass in European subjects with type 2 diabetes.
Decreases in both beta-cell function and number can contribute to insulin deficiency in type 2 diabetes. Here, we quantified the… (More)
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Review
2007
Review
2007
beta-cell failure in diabetes and preservation by clinical treatment.
There is a progressive deterioration in beta-cell function and mass in type 2 diabetics. It was found that islet function was… (More)
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Highly Cited
2005
Highly Cited
2005
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.
The nature of the progressive beta-cell failure occurring as normal glucose tolerant (NGT) individuals progress to type 2… (More)
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Highly Cited
2004
Highly Cited
2004
C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.
The underlying cause of type 1 diabetes, loss of beta-cell function, has become the therapeutic target for a number of… (More)
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Review
2003
Review
2003
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes have been… (More)
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Highly Cited
2002
Highly Cited
2002
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study
BACKGROUND Glucagon-like peptide 1 (GLP-1) has been proposed as a treatment for type 2 diabetes. We have investigated the long… (More)
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Highly Cited
2002
Highly Cited
2002
Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women.
Type 2 diabetes frequently results from progressive failure of pancreatic beta-cell function in the presence of chronic insulin… (More)
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Highly Cited
1999
Highly Cited
1999
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Oxidative stress is produced under diabetic conditions and possibly causes various forms of tissue damage in patients with… (More)
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Highly Cited
1993
Highly Cited
1993
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.
To determine the relationship between insulin sensitivity and beta-cell function, we quantified the insulin sensitivity index… (More)
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