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BNIP3 gene

Known as: BCL2/ADENOVIRUS E1B 19-KD PROTEIN-INTERACTING PROTEIN 3, BCL2/adenovirus E1B 19kDa interacting protein 3, BNIP3 
This gene plays a role in the stimulation of both apoptosis and autophagy.
National Institutes of Health

Related topics

Related topics

3 relations
ApoptosisAutophagyPositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Expanding perspectives on the significance of mitophagy in cancer.
Highly Cited
2014
Highly Cited
2014
BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke
A basal level of mitophagy is essential in mitochondrial quality control in physiological conditions, while excessive mitophagy… 
Highly Cited
2014
Highly Cited
2014
Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling
Significance We provide new, exciting evidence for a previously unidentified signaling pathway that mechanistically links… 
Highly Cited
2008
Highly Cited
2008
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L
Macroautophagy (called autophagy hereafter) is a catabolic process activated by various types of stress, most notably by nutrient… 
Review
2008
Review
2008
BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions
The BNIP3 subfamily of BH3-only proteins consists of BNIP3 and BNIP3-like (BNIP3L) proteins. These proteins form stable… 
Highly Cited
2007
Highly Cited
2007
Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model
Concanavalin A (ConA), a lectin with mannose specificity that can induce acute hepatic inflammation, was tested for its… 
Highly Cited
2005
Highly Cited
2005
Intrinsic Chemoresistance to Gemcitabine Is Associated with Decreased Expression of BNIP3 in Pancreatic Cancer
Purpose: Although chemotherapy with gemcitabine is a common mode of treatment of pancreatic cancer, 75% of patients do not… 
Highly Cited
2005
Highly Cited
2005
Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.
BNIP3 protein is a proapoptotic member of the Bcl-2 family that is expressed in hypoxic regions of tumors. To examine its role in… 
Highly Cited
2004
Highly Cited
2004
Silencing of the Hypoxia-Inducible Cell Death Protein BNIP3 in Pancreatic Cancer
Hypoxic conditions exist within pancreatic adenocarcinoma, yet pancreatic cancer cells survive and replicate within this… 
Highly Cited
2003
Highly Cited
2003
BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF
Hypoxic regions within solid tumors are often resistant to chemotherapy and radiation. BNIP3 (Bcl-2/E1B 19 kDa interacting… 
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