BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

@article{Chinnadurai2008BNIP3SB,
  title={BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions},
  author={G. Chinnadurai and S. Vijayalingam and Spencer B Gibson},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={S114-S127}
}
The BNIP3 subfamily of BH3-only proteins consists of BNIP3 and BNIP3-like (BNIP3L) proteins. These proteins form stable homodimerization complexes that localize to the outer membrane of the mitochondria after cellular stress. This promotes either apoptotic or non-apoptotic cell death such as autophagic cell death. Although the mammalian cells contain both… CONTINUE READING