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BMS 214662

Known as: BMS-214662, BMS214662, FTI BMS 214662 
A nonsedating benzodiazepine derivative with potential antineoplastic activity. Farnesyltransferase inhibitor BMS-214662 inhibits the enzyme… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Chronic myeloid leukemia (CML), a hematopoietic stem-cell disorder, cannot be eradicated by conventional chemotherapy or the… Expand
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Review
2004
Review
2004
  • H. Mo, C. Elson
  • Experimental biology and medicine
  • 2004
  • Corpus ID: 29604225
Pools of farnesyl diphosphate and other phosphorylated products of the mevalonate pathway are essential to the post-translational… Expand
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Highly Cited
2002
Highly Cited
2002
The development of chronic myeloid leukemia (CML) is dependent on the deregulated tyrosine kinase of the oncoprotein BCR-ABL… Expand
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Highly Cited
2002
Highly Cited
2002
Inflammatory breast carcinoma (IBC) is a highly aggressive form of locally advanced breast cancer that has the ability to invade… Expand
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Highly Cited
2001
Highly Cited
2001
BCR/ABL, the oncoprotein responsible for chronic myeloid leukemia (CML), transforms hematopoietic cells through both Ras… Expand
Highly Cited
2001
Highly Cited
2001
BMS-214662 is a potent and selective inhibitor of farnesyltransferase (FTI). In rodent fibroblasts transformed by oncogenes, BMS… Expand
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Highly Cited
2000
Highly Cited
2000
Farnesyltransferase inhibitors (FTIs) were developed to target abnormal signaling pathways that are commonly activated in… Expand
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Highly Cited
2000
Highly Cited
2000
Continuing structure-activity studies were performed on the 2,3,4, 5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine… Expand
Highly Cited
1997
Highly Cited
1997
Protein farnesyltransferase inhibitors (FTIs) inhibit Ras transformation and Ras-dependent tumor cell growth, but the biological… Expand
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Highly Cited
1997
Highly Cited
1997
Farnesyl transferase inhibitors (FTIs) are a novel class of antitumor drugs that block the oncogenic activity of Ras. Because… Expand
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