BMS 214662

Known as: BMS-214662, BMS214662, FTI BMS 214662 
A nonsedating benzodiazepine derivative with potential antineoplastic activity. Farnesyltransferase inhibitor BMS-214662 inhibits the enzyme… (More)
National Institutes of Health

Papers overview

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2011
2011
The cytotoxic farnesyl transferase inhibitor BMS-214662 has been shown to potently induce mitochondrial apoptosis in primitive… (More)
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Highly Cited
2008
Highly Cited
2008
Chronic myeloid leukemia (CML), a hematopoietic stem-cell disorder, cannot be eradicated by conventional chemotherapy or the… (More)
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2005
2005
PURPOSE To investigate the dose-limiting toxicity (DLT) and maximum-tolerated dose (MTD) of BMS-214662, a farnesyl transferase… (More)
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2005
2005
We have studied the mechanism of apoptosis elicited by the farnesyltransferase inhibitor (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H… (More)
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2004
2004
B-cell chronic lymphocytic leukemia (B-CLL) cells develop resistance to nucleoside analogs over time. This chemoresistance may be… (More)
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2004
2004
The search for new cancer therapeutics has identified protein farnesyltransferase (FTase) as a promising drug target. This enzyme… (More)
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Highly Cited
2002
Highly Cited
2002
The development of chronic myeloid leukemia (CML) is dependent on the deregulated tyrosine kinase of the oncoprotein BCR-ABL… (More)
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2001
2001
BMS-214662 is a potent and selective inhibitor of farnesyltransferase (FTI). In rodent fibroblasts transformed by oncogenes, BMS… (More)
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Highly Cited
1997
Highly Cited
1997
Farnesyl transferase inhibitors (FTIs) are a novel class of antitumor drugs that block the oncogenic activity of Ras. Because… (More)
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