Radiation Sensitization by Inhibition of Activated Ras

@article{Brunner2004RadiationSB,
  title={Radiation Sensitization by Inhibition of Activated Ras},
  author={Thomas Baptist Brunner and Stephen M. Hahn and W. Gillies Mckenna and Eric J. Bernhard},
  journal={Strahlentherapie und Onkologie},
  year={2004},
  volume={180},
  pages={731-740}
}
Ras has been identified as a significant contributor to radiation resistance. This article reviews preclinical and phase I clinical studies that reported on combining inhibition of activated Ras and downstream effectors of Ras with radiotherapy. Transfection studies and RNA interference were used to check the role of the Ras isoforms for intrinsic radiation sensibility. Western blotting was used to control for prenylation inhibition of the respective Ras isoforms and for changes in activity of… CONTINUE READING
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