• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi‐chaperone complex in human epidermoid cancer cells
TLDR
It is demonstrated for the first time that MW‐EMF induces apoptosis through the inactivation of the ras → Erk survival signaling due to enhanced degradation of ras and Raf‐1 determined by decreased expression of HSP90 and the consequent increase of proteasome dependent degradation. Expand
Mir-34: A New Weapon Against Cancer?
TLDR
Given the broad anti-oncogenic activity of miR-34a, the replacement of oncosuppressor miRNAs provides an effective strategy against tumor heterogeneity and the selective RNA-based delivery systems seems to be an excellent platform for a safe and effective targeting of the tumor. Expand
Alpha‐interferon and its effects on signal transduction pathways
TLDR
A reactive mechanism of protection of tumor cells from the apoptosis induced by IFNα dependent on the epidermal growth factor‐mediated Ras/extracellular signal regulated kinase (Erk) signaling is described, suggesting that the specific disruption of the latter could be a useful approach to potentiate the antitumour activity of IFN α against human tumors. Expand
miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1
TLDR
It is demonstrated that the PI3K/AKT pathway plays a major role in the regulation of miR-29b-Sp1 loop and induction of apoptosis in MM cells and MM xenografts constitutively expressing miR -29b showed significant reduction of their tumorigenic potential. Expand
Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview
TLDR
The detection of molecular factors predictive of response to anti-cancer agents such as sorafenib and the identification of mechanisms of resistance toAnti- cancer agents may probably represent the direction to improve the treatment of HCC. Expand
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
TLDR
Findings support a key role of the ROS-dependent activation of an autophagic program in the synergistic growth inhibition induced by GEM/cannabinoid combination in human pancreatic cancer cells. Expand
Repeated Intermittent Low-Dose Therapy with Zoledronic Acid Induces an Early, Sustained, and Long-Lasting Decrease of Peripheral Vascular Endothelial Growth Factor Levels in Cancer Patients
TLDR
It is reported that a repeated low-dose therapy with ZA is able to induce an early significant and long-lasting decrease of VEGF levels in cancer patients. Expand
Familial papillary thyroid microcarcinoma: a new clinical entity
TLDR
The unfavourable behaviour in the familial form of papillary thyroid microcarcinoma suggests that radical treatment and careful follow-up are warranted. Expand
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro
TLDR
It is demonstrated that ZOL induces growth inhibition and apoptosis on PC cells and interferes with growth and survival pathways downstream to p21ras, which might be relevant for expanding application of BPs in cancer treatment. Expand
...
1
2
3
4
5
...