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protein farnesyltransferase

Known as: Farnesyl Protein Transferase, Farnesyl Transferase, Farnesyltransferase 
A heterodimeric enzyme (alpha and beta subunits) that catalyzes the addition of farnesyl groups, as farnesyl diphosphate, to the C termini of… Expand
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Mutation of the KRAS oncogene in pancreatic cancer is responsible for permanent activation of the P21 RAS protein and the cascade… Expand
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Highly Cited
2006
Highly Cited
2006
Progerias are rare genetic diseases characterized by premature aging. Several progeroid disorders are caused by mutations that… Expand
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Review
2005
Review
2005
Although improvement in outcomes has occurred in younger adults with acute myeloid leukemia (AML) during the past 4 decades… Expand
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Highly Cited
2005
Highly Cited
2005
Hutchinson-Gilford progeria syndrome (HGPS), a progeroid syndrome in children, is caused by mutations in LMNA (the gene for… Expand
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Highly Cited
2005
Highly Cited
2005
Defects in the biogenesis of lamin A from its farnesylated precursor, prelamin A, lead to the accumulation of prelamin A at the… Expand
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Review
2005
Review
2005
Hepatocellular carcinoma is often diagnosed at an advanced stage, when it is not amenable to curative therapies. There is no… Expand
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Highly Cited
2004
Highly Cited
2004
Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of host lipid raft–associated receptors, a… Expand
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Highly Cited
2000
Highly Cited
2000
Bisphosphonates are the important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Although their… Expand
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Review
1999
Review
1999
Ras proteins are guanine nucleotide-binding proteins that play pivotal roles in the control of normal and transformed cell growth… Expand
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Highly Cited
1997
Highly Cited
1997
The association of mutant forms of Ras protein with a variety of human cancers has stimulated intense interest in therapies based… Expand
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