protein farnesyltransferase

Known as: Farnesyl Protein Transferase, Farnesyl Transferase, Farnesyltransferase 
A heterodimeric enzyme (alpha and beta subunits) that catalyzes the addition of farnesyl groups, as farnesyl diphosphate, to the C termini of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2018
05101519862018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Progerias are rare genetic diseases characterized by premature aging. Several progeroid disorders are caused by mutations that… (More)
Is this relevant?
2005
2005
The post-translational farnesylation of proteins serves to anchor a subset of intracellular proteins to membranes in eukaryotic… (More)
  • table I
  • figure 1
  • figure 2
  • table II
  • figure 4
Is this relevant?
2002
2002
Protein farnesyltransferase (FTase) catalyses the attachment of a farnesyl lipid group to numerous essential signal transduction… (More)
Is this relevant?
2002
2002
Comparison of the malaria parasite and mammalian protein prenyltransferases and their cellular substrates is important for… (More)
  • table I
  • table II
Is this relevant?
Highly Cited
2001
Highly Cited
2001
R115777 is a nonpeptidomimetic enzyme-specific inhibitor of farnesyl protein transferase (FT) that was developed as a potential… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Is this relevant?
1997
1997
Protein farnesyltransferase (FTase) catalyzes the carboxyl-terminal lipidation of Ras and several other cellular signal… (More)
Is this relevant?
1996
1996
The structures of new protein farnesyltransferase inhibitors, andrastins A-C, were elucidated. The cyclopentane ring of… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
1991
1991
The protein farnesyltransferase from rat brain was previously shown to be inhibited competitively by tetrapeptides that conform… (More)
Is this relevant?
1991
1991
We tested 42 tetrapeptides for their ability to bind to the rat brain p21ras protein farnesyltransferase as estimated by their… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 2
  • table 1
Is this relevant?