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protein farnesyltransferase

Known as: Farnesyl Protein Transferase, Farnesyl Transferase, Farnesyltransferase 
A heterodimeric enzyme (alpha and beta subunits) that catalyzes the addition of farnesyl groups, as farnesyl diphosphate, to the C termini of… 
National Institutes of Health

Papers overview

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Review
2006
Highly Cited
2005
Highly Cited
2005
Hutchinson-Gilford progeria syndrome (HGPS), a progeroid syndrome in children, is caused by mutations in LMNA (the gene for… 
Review
2005
Review
2005
Although improvement in outcomes has occurred in younger adults with acute myeloid leukemia (AML) during the past 4 decades… 
Highly Cited
2005
Highly Cited
2005
Acute myelogenous leukemia (AML) is a disorder marked by infiltration of the bone marrow by abnormal hematopoietic progenitors… 
Review
2003
Review
2003
Within the last 15 years, multiple new signal transduction pathways within cells have been discovered. Many of these pathways… 
Highly Cited
2001
Highly Cited
2001
R115777 [(B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] is a… 
Review
1999
Review
1999
Ras proteins are guanine nucleotide-binding proteins that play pivotal roles in the control of normal and transformed cell growth… 
Highly Cited
1997
Highly Cited
1997
The association of mutant forms of Ras protein with a variety of human cancers has stimulated intense interest in therapies based… 
Highly Cited
1997
Highly Cited
1997
This study explores the role of mevalonate inhibitors in the activation of NF-kbeta and the induction of inducible nitric oxide… 
Highly Cited
1993
Highly Cited
1993
To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue…