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protein farnesyltransferase
Known as:
Farnesyl Protein Transferase
, Farnesyl Transferase
, Farnesyltransferase
A heterodimeric enzyme (alpha and beta subunits) that catalyzes the addition of farnesyl groups, as farnesyl diphosphate, to the C termini of…
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National Institutes of Health
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Related topics
Related topics
8 relations
BMS 214662
FNTA protein, human
FNTB protein, human
Farnesyl-diphosphate farnesyltransferase
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Broader (1)
Transferase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Thematic review series: Lipid Posttranslational Modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I Published, JLR Papers in Press, February 13, 2006…
Kimberly T. Lane
,
L. Beese
Journal of Lipid Research
2006
Corpus ID: 7435639
More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational…
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Highly Cited
2005
Highly Cited
2005
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.
Shao H. Yang
,
M. Bergo
,
+8 authors
L. Fong
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 19397048
Hutchinson-Gilford progeria syndrome (HGPS), a progeroid syndrome in children, is caused by mutations in LMNA (the gene for…
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Review
2005
Review
2005
Drug therapy for acute myeloid leukemia.
M. Tallman
,
D. Gilliland
,
J. Rowe
,
R. Lurie
Blood
2005
Corpus ID: 16227119
Although improvement in outcomes has occurred in younger adults with acute myeloid leukemia (AML) during the past 4 decades…
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Highly Cited
2005
Highly Cited
2005
Acute Myelogenous Leukemia
H. Ghaddar
,
E. Estey
2005
Corpus ID: 11466675
Acute myelogenous leukemia (AML) is a disorder marked by infiltration of the bone marrow by abnormal hematopoietic progenitors…
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Review
2003
Review
2003
MAPK pathways in radiation responses
P. Dent
,
A. Yacoub
,
P. Fisher
,
M. Hagan
,
S. Grant
Oncogene
2003
Corpus ID: 20849479
Within the last 15 years, multiple new signal transduction pathways within cells have been discovered. Many of these pathways…
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Highly Cited
2001
Highly Cited
2001
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
D. End
,
G. Smets
,
+10 authors
C. Bowden
Cancer Research
2001
Corpus ID: 8599702
R115777 [(B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] is a…
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Review
1999
Review
1999
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.
E. Rowinsky
,
J. Windle
,
D. D. Hoff
Journal of Clinical Oncology
1999
Corpus ID: 12832014
Ras proteins are guanine nucleotide-binding proteins that play pivotal roles in the control of normal and transformed cell growth…
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Highly Cited
1997
Highly Cited
1997
K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors*
D. Whyte
,
P. Kirschmeier
,
+5 authors
J. Pai
Journal of Biological Chemistry
1997
Corpus ID: 21932968
The association of mutant forms of Ras protein with a variety of human cancers has stimulated intense interest in therapies based…
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Highly Cited
1997
Highly Cited
1997
Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.
K. Pahan
,
F. Sheikh
,
A. Namboodiri
,
I. Singh
Journal of Clinical Investigation
1997
Corpus ID: 13094601
This study explores the role of mevalonate inhibitors in the activation of NF-kbeta and the induction of inducible nitric oxide…
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Highly Cited
1993
Highly Cited
1993
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor.
N. Kohl
,
S. Mosser
,
+7 authors
J. Gibbs
Science
1993
Corpus ID: 8829624
To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue…
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