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BIBN 99

Known as: BIBN-99 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2002
01219932002

Related topics

Related topics

2 relations

Broader (2)

DibenzazepinesPyridines

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
BIBN 99
Pyridines
Dibenzazepines

Papers overview

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2003
2003
Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats.
Aged Long-Evans rats were screened for spatial memory deficits using the Morris water maze task. Rats found to have impaired… (More)
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Highly Cited
2002
Highly Cited
2002
Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats.
Hippocampal-dependent learning and memory deficits have been well documented in aging rodents. The results of several recent… (More)
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Highly Cited
2001
Highly Cited
2001
Acetylcholine mediates the estrogen-induced increase in NMDA receptor binding in CA1 of the hippocampus and the associated improvement in working memory.
Elevated levels of circulating estrogen in female rats result in increased spine and synapse density and parallel increases in… (More)
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2001
2001
Effects of metrifonate on the hippocampal theta rhythm of freely moving intact and MS-lesioned mice.
Changes in hippocampal electroencephalogram (EEG) have been suggested to be closely associated with spatial learning ability… (More)
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1998
1998
Alzheimer's disease therapy - an update.
The 5th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy focused on new therapeutic approaches for the… (More)
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1997
1997
Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain.
Amyloid deposits in Alzheimer's disease are composed of amyloid beta-peptides (A beta) that are derived from the larger amyloid… (More)
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1997
1997
The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats.
The present study examined the role of muscarinic receptors in the discriminative stimulus properties of clozapine. One group of… (More)
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1995
1995
Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats.
Mild to moderate traumatic brain injury (TBI) is associated with enduring impairments of cognitive function in both humans and… (More)
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Highly Cited
1995
Highly Cited
1995
Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired.
Aged memory-impaired (AI) and unimpaired (AU) 24-25-month-old Long-Evans rats were used to investigate the integrity of various… (More)
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1993
1993
Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist.
The present study was designed to characterize the receptor selectivity profile of the novel muscarinic M2 receptor antagonist… (More)
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