• Publications
  • Influence
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.
  • M. Meaney
  • Psychology, Biology
    Annual review of neuroscience
  • 2001
TLDR
Evidence is provided for the importance of parental care as a mediator of the effects of environmental adversity on neural development and patterns of maternal care that increase stress reactivity in offspring are enhanced by stressors imposed on the mother.
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.
TLDR
It is suggested that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
TLDR
Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
Nongenomic transmission across generations of maternal behavior and stress responses in the rat.
TLDR
Results of cross-fostering studies reported here indicate that variations in maternal care can serve as the basis for a nongenomic behavioral transmission of individual differences in stress reactivity across generations.
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat.
TLDR
It is suggested that maternal care during infancy serves to "program" behavioral responses to stress in the offspring by altering the development of the neural systems that mediate fearfulness.
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors
TLDR
It is suggested that maternal licking/grooming influences the development of estrogen sensitivity in brain regions that regulate maternal behavior, providing a potential mechanism for the intergenerational transmission of individual differences in maternal behavior.
Effect of neonatal handling on age-related impairments associated with the hippocampus.
TLDR
A subtle manipulation early in life can retard the emergence of a complex degenerative cascade of aging in the rat, including glucocorticoid hypersecretion, hippocampal neuron death, and cognitive impairments.
Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [11C]Raclopride
TLDR
It is suggested that aversive stressful events can be associated with mesolimbic dopamine release in humans, and that the method presented here may be useful to study the effects of early life events on neurobiological stress systems.
Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress
TLDR
It is suggested that maternal effects may modulate optimal cognitive functioning in environments varying in demand in later life, with offspring of high and low LG mothers showing enhanced learning under contexts of low and high stress, respectively.
...
...