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The gut microbiota influences blood-brain barrier permeability in mice
TLDR
It is shown that germ-free pregnant dams, devoid of maternal microbes, have offspring that show increased permeability of the blood-brain barrier, suggesting that crosstalk between the gut microbiota and the brain, initiated during the intrauterine period, is perpetuated throughout life. Expand
Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.
TLDR
This finding indicates that neuroleptic-induced extrapyramidal syndromes are related to the degree of central D2 occupancy induced in the basal ganglia of drug-treated schizophrenic patients and demonstrates that clozapine is also "atypical" with respect to the central D1 occupancy in patients. Expand
A PET study of
TLDR
The results support the view that [11C]ß-CIT-FE is a suitable radioligand for clinical studies of the dopamine transporter, in particular for studies requiring short data acquisition or repeated PET measurements on the same day. Expand
Kinetic Analysis of Central [11C]Raclopride Binding to D2-Dopamine Receptors Studied by PET—A Comparison to the Equilibrium Analysis
TLDR
Examination of [11C]raclopride uptake in brain regions devoid of specific D2-dopamine receptor binding indicated a fourth compartment in which uptake was reversible, nonstereoselective, and nonsaturable in the dose range studied. Expand
Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: A double-blind PET study of schizophrenic patients
TLDR
The finding of a relationship between selective occupancy of the D2-dopamine receptors and clinical effects in schizophrenic patients principally provides new support for the dopamine hypothesis of antipsychotic drug action. Expand
Age-related cognitive deficits mediated by changes in the striatal dopamine system.
TLDR
D(2) receptor binding is a more important factor than chronological age in accounting for variation in cognitive performance across the adult lifespan, and changes in dopamine neurotransmission play an important role in aging-related cognitive decline. Expand
Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]WAY-100635
TLDR
The selective labeling of 5-HT1A receptors with [3H]WAY-100635 clearly show that this compound is useful for further studies of the human 5- HT1a receptor subtype in vivo and provides a strong basis for expecting [11C]Way- 100635 to behave as a highly selective radioligand in vivo. Expand
Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients.
TLDR
To achieve this, resperidone, 4 mg/day, should be a suitable initial dose for antipsychotic effect with a minimal risk of extrapyramidal side effects in most patients. Expand
Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs.
TLDR
Clinical doses of all the currently used classes of antipsychotic drugs cause a substantial blockade of central D2-dopamine receptors in humans, and this effect appears to be selective for the antipsychotics. Expand
Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
TLDR
Both dopamine receptor subtypes, as well as dopamine, HVA and DOPAC, were primarily found in the basal ganglia, and the receptor distribution in the autoradiographic study was consistent with that demonstrated in the living human brain using [11C]. Expand
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