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BCL11A gene

Known as: EVI9, MOUSE, HOMOLOG OF, EVI9, B-Cell CLL/Lymphoma 11A (Zinc Finger Protein) Gene 
This gene is involved in both the modulation of cell shape and lymphopoiesis.
National Institutes of Health

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Related topics

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B-Cell Lymphoma/Leukemia 11ABCL11A protein, humanHematopoiesisRegulation of Cell Shape

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BCL11A wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Comparative analysis of lentiviral gene transfer approaches designed to promote fetal hemoglobin production for the treatment of β-hemoglobinopathies.
2016
2016
Genetic Variants at BCL11A and HBS1L-MYB loci Influence Hb F Levels in Chinese Zhuang β-Thalassemia Intermedia Patients
Abstract Increased Hb F levels can ameliorate the symptoms of β-thalassemia (β-thal). Due to the genetic heterogenicity of β-thal… 
2015
2015
Association between Variants at BCL11A Erythroid-Specific Enhancer and Fetal Hemoglobin Levels among Sickle Cell Disease Patients in Cameroon: Implications for Future Therapeutic Interventions.
Variants in BCL11A were previously associated with fetal hemoglobin (HbF) levels among Cameroonian sickle cell disease (SCD… 
2012
2012
Fetal hemoglobin in sickle cell anemia: Molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans
Fetal hemoglobin (HbF) is a major modifier of disease severity in sickle cell anemia (SCA). Three major HbF quantitative trait… 
2012
2012
Novel therapeutic agents for HbF induction: a new era for treatment of β thalassemia?
Fetal globin is endogenous, normally integrated in hematopoietic stem cells in all humans, and available for reactivation… 
2012
2012
Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial
Abstract 753 Sickle cell disease (SCD) is caused by a mutation in the β-globin protein, leading to the polymerization of… 
Review
2010
Review
2010
Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus.
2010
2010
Bcl11A/CTIP1 mediates the effect of the glutamate receptor on axon branching and dendrite outgrowth
J. Neurochem. (2010) 114, 1381–1392. 
Highly Cited
2003
Highly Cited
2003
Recruitment of Tat to Heterochromatin Protein HP1 via Interaction with CTIP2 Inhibits Human Immunodeficiency Virus Type 1 Replication in Microglial Cells
ABSTRACT The Tat protein of human immunodeficiency virus type 1 (HIV-1) plays a key role as inducer of viral gene expression. We… 
Highly Cited
2000
Highly Cited
2000
Evi9 Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene Product
ABSTRACT Evi9 is a common site of retroviral integration in BXH2 murine myeloid leukemias. Here we show that Evi9 encodes a novel… 
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