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B-Cell Lymphoma/Leukemia 11A

Known as: Zinc Finger Protein 856, BCL-11A, EVI-9 
B-cell lymphoma/leukemia 11A (835 aa, ~91 kDa) is encoded by the human BCL11A gene. This protein is involved in the regulation of both cell… 
National Institutes of Health

Related topics

Related topics

6 relations
BCL11A geneBCL11A wt AlleleCYS2-HIS2 Zinc FingersGenes, Regulator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.
Reducing expression of the fetal hemoglobin (HbF) repressor BCL11A leads to a simultaneous increase in γ-globin expression and… 
Highly Cited
2015
Highly Cited
2015
BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.
A transition from fetal hemoglobin (HbF) to adult hemoglobin (HbA) normally occurs within a few months after birth. Increased… 
Highly Cited
2011
Highly Cited
2011
Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing
Manipulation of a transcriptional repressor promotes expression of protective fetal globin genes. Persistence of human fetal… 
Highly Cited
2011
Highly Cited
2011
A functional element necessary for fetal hemoglobin silencing.
BACKGROUND An improved understanding of the regulation of the fetal hemoglobin genes holds promise for the development of… 
Highly Cited
2011
Highly Cited
2011
Nilotinib treatment‐associated peripheral artery disease and sudden death: Yet another reason to stick to imatinib as front‐line therapy for chronic myelogenous leukemia
A new sequential regimen for allogeneic stem-cell transplantation, comprising cytoreductive chemotherapy immediately followed by… 
Highly Cited
2008
Highly Cited
2008
BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies.
Highly Cited
2008
Highly Cited
2008
Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
Plasmacytoid dendritic cells (pDCs) are involved in innate immunity (eg, by secreting interferons) and also give rise to CD4+CD56… 
Highly Cited
2008
Highly Cited
2008
Comparative genome profiling across subtypes of low-grade B-cell lymphoma identifies type-specific and common aberrations that target genes with a role in B-cell neoplasia
Low-grade B-cell lymphomas are very heterogeneous. This study of comparative genome profiling identifies type-specific… 
Highly Cited
2002
Highly Cited
2002
Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.
Comparative genomic hybridization studies have shown gains in chromosome region 2p as the most common imbalance in classical… 
Highly Cited
2000
Highly Cited
2000
Evi9 Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene Product
ABSTRACT Evi9 is a common site of retroviral integration in BXH2 murine myeloid leukemias. Here we show that Evi9 encodes a novel… 
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