Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
This work identified target promoters of nine transcription factors, including somatic cell reprogramming factors (Oct4, Sox2, Klf4, and c-Myc) and others and broadly distinguish targets of c- myc versus other factors on a global scale in mouse ES cells. Expand
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Studies of hematopoiesis provide critical insights of general relevance to other areas of stem cell biology including the role of cellular interactions in development and tissue homeostasis, lineage programming and reprogramming by transcription factors, and stage- and age-specific differences in cellular phenotypes. Expand
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
EZH1 partially complements Ezh2 in executing pluripotency during ESC differentiation, suggesting that cell-fate transitions require epigenetic specificity. Expand
A protein interaction network for pluripotency of embryonic stem cells
This tight protein network seems to function as a cellular module dedicated to pluripotency in mouse ES cells, linked to multiple co-repressor pathways and composed of numerous proteins whose encoding genes are putative direct transcriptional targets of its members. Expand
An early haematopoietic defect in mice lacking the transcription factor GATA-2
It is demonstrated that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type, and proposed that it regulates genes controlling growth factor responsiveness or the proliferative capacity of early haem atopoietic cells. Expand
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
5hmC is an epigenetic modification associated with the pluripotent state, and Tet1 functions to regulate the lineage differentiation potential of ESCs. Expand
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
- R. Arceci, A. A. King, M. Simon, S. Orkin, D. Wilson
- Biology, Medicine
- Molecular and cellular biology
- 1 April 1993
It is concluded that GATA-4 is a tissue-specific, retinoic acid-inducible, and developmentally regulated transcription factor that plays a role in gene expression in the heart, intestinal epithelium, primitive endoderm, and gonads. Expand
The placenta is a niche for hematopoietic stem cells.
- C. Gekas, F. Dieterlen‐Lièvre, S. Orkin, H. Mikkola
- Biology, Medicine
- Developmental cell
- 16 November 2004
It is shown that the mouse placenta functions as a hematopoietic organ that harbors a large pool of pluripotent HSCs during midgestation, and the expansion of the CD34(+)c-kit(+) HSC pool in the Placenta occurs prior to and during the initial expansion of HSCS in the fetal liver. Expand
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
It is demonstrated that the conditional expression of an endogenous K-ras(G12D) allele in murine embryonic fibroblasts causes enhanced proliferation and partial transformation in the absence of further genetic abnormalities. Expand
Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
Gene targeting was used to generate mice with a null allele of the gene involved in X–linked CGD, which encodes the 91 kD subunit of the oxidase cytochrome b, and affected hemizygous male mice lacked phagocyte superoxide production and had an altered inflammatory response in thioglycollate peritonitis. Expand