An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
An early haematopoietic defect in mice lacking the transcription factor GATA-2
It is demonstrated that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type, and proposed that it regulates genes controlling growth factor responsiveness or the proliferative capacity of early haem atopoietic cells.
A protein interaction network for pluripotency of embryonic stem cells
This tight protein network seems to function as a cellular module dedicated to pluripotency in mouse ES cells, linked to multiple co-repressor pathways and composed of numerous proteins whose encoding genes are putative direct transcriptional targets of its members.
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart
- R. Arceci, A. A. King, M. Simon, S. Orkin, D. Wilson
- BiologyMolecular and Cellular Biology
- 1 April 1993
It is concluded that GATA-4 is a tissue-specific, retinoic acid-inducible, and developmentally regulated transcription factor that plays a role in gene expression in the heart, intestinal epithelium, primitive endoderm, and gonads.
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
Gene targeting was used to generate mice with a null allele of the gene involved in X–linked CGD, which encodes the 91 kD subunit of the oxidase cytochrome b, and affected hemizygous male mice lacked phagocyte superoxide production and had an altered inflammatory response in thioglycollate peritonitis.
A comparative encyclopedia of DNA elements in the mouse genome
By comparing with the human genome, this work not only confirms substantial conservation in the newly annotated potential functional sequences, but also finds a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization.