FAQ

Arachidonate 12-Lipoxygenase

Known as: Arachidonic Acid 12-Lipoxygenase, Arachidonate 12 Lipoxygenase, 12-Lipoxygenase, Arachidonate 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2017
024619822017

Related topics

Related topics

11 relations

Narrower (1)

12-15-lipoxygenase
ALOX12 geneALOX12B geneIn BloodProcess of secretion
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Arachidonate 12-Lipoxygenase
physiological aspects
chemical synthesis
standards characteristics
Process of secretion
ALOX12 gene

Papers overview

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2010
2010
12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets.
CONTEXT Inflammation is increasingly recognized as an important contributing factor in diabetes mellitus. Lipoxygenases (LOs… (More)
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2008
2008
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.
Inflammation is a key pathological process in the progression of atherosclerosis and type 2 diabetes. 12/15-lipoxygenase (12-LO… (More)
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2006
2006
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
12-Lipoxygenase utilizes arachidonic acid to synthesize 12(S)-hydroperoxyeicosatetraenoic acid, which is converted to the end… (More)
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Highly Cited
2002
Highly Cited
2002
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
Extensive studies have implicated the role of dietary fatty acids in prostatecancer progression. Platelet-type 12-Lipoxygenase… (More)
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2001
2001
12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.
Arachidonic acid release from membrane phospholipids is essential for tumour cell proliferation. Lipoxygenases constitute a… (More)
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2001
2001
Ribozyme-mediated inhibition of rat leukocyte-type 12-lipoxygenase prevents intimal hyperplasia in balloon-injured rat carotid arteries.
BACKGROUND 12-Lipoxygenase (12-LO) products of arachidonate metabolism have growth and chemotactic effects in vascular smooth… (More)
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1995
1995
Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells.
Arachidonate 12-lipoxygenase is an enzyme that oxygenates the 12 position of arachidonic acid to produce its 12-hydroperoxy… (More)
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1994
1994
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
12(S)-Hydroxyeicosatetraenoic acid [12(S)-HETE] is the 12-lipoxygenase metabolite of arachidonic acid. Previously, we have… (More)
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1993
1993
Arachidonate 12-lipoxygenase is localized in neurons, glial cells, and endothelial cells of the canine brain.
12-Lipoxygenase oxygenates the 12 position of arachidonic acid, producing its 12S-hydroperoxy derivative. We have been interested… (More)
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1992
1992
Localization of arachidonate 12-lipoxygenase in canine brain tissues.
The cytosol fraction from a thoroughly irrigated canine cerebrum was subjected to immunoaffinity chromatography using a… (More)
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