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Arachidonate 12-Lipoxygenase
Known as:
Arachidonic Acid 12-Lipoxygenase
, Arachidonate 12 Lipoxygenase
, 12-Lipoxygenase, Arachidonate
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An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a…
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National Institutes of Health
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Related topics
Related topics
11 relations
Narrower (3)
12-15-lipoxygenase
Alox12b protein, mouse
hepoxilin synthase
ALOX12 gene
ALOX12B gene
In Blood
Process of secretion
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase Published, JLR Papers in Press, February 5, 2006.
J. Huber
,
A. Fürnkranz
,
+6 authors
N. Leitinger
Journal of Lipid Research
2006
Corpus ID: 1240680
Oxidized phospholipids stimulate endothelial cells to bind monocytes, but not neutrophils, an initiating event in atherogenesis…
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Highly Cited
1995
Highly Cited
1995
A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells. Evidence for upregulation by angiotensin II.
J. A. Kim
,
J. Gu
,
R. Natarajan
,
J. Berliner
,
J. Nadler
Arteriosclerosis, Thrombosis and Vascular Biology
1995
Corpus ID: 20493824
The lipoxygenase (LO) pathway has been implicated in leading to accelerated atherosclerosis. However, the precise type of LO…
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Highly Cited
1993
Highly Cited
1993
Molecular cloning of a 12-lipoxygenase cDNA from rat brain.
Takashi Watanabe
,
Juan F. Medina
,
J. Haeggström
,
O. Rådmark
,
B. Samuelsson
European Journal of Biochemistry
1993
Corpus ID: 30118928
A cDNA encoding an arachidonate 12-lipoxygenase from rat brain was obtained by polymerase chain reaction cloning. Primers…
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Highly Cited
1993
Highly Cited
1993
Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases.
Y. Takahashi
,
W. Glasgow
,
+5 authors
A. Brash
European Journal of Biochemistry
1993
Corpus ID: 26868932
When arachidonate 12-lipoxygenase purified from porcine leukocytes was incubated aerobically with 1-palmitoyl-2-arachidonoyl-sn…
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Highly Cited
1991
Highly Cited
1991
Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction.
Colin D. Funk
,
G. FitzGerald
Journal of Biological Chemistry
1991
Corpus ID: 24775898
Highly Cited
1986
Highly Cited
1986
Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer.
P. Kuhl
,
H. Borbe
,
H. Fischer
,
A. Römer
,
H. Safayhi
Prostaglandins
1986
Corpus ID: 23384815
Highly Cited
1986
Highly Cited
1986
Lipoxygenase in trout gill tissue acting on arachidonic, eicosapentaenoic and docosahexaenoic acids.
J. German
,
G. Bruckner
,
J. Kinsella
Biochimica et Biophysica Acta
1986
Corpus ID: 31747172
Review
1985
Review
1985
A review of possible roles of the platelet 12-lipoxygenase.
A. Brash
Circulation
1985
Corpus ID: 10186778
THE 12-LIPOXYGENASE ENZYME of platelets was the first lipoxygenase to be discovered in animal tissue,1 yet its physiologic…
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Highly Cited
1983
Highly Cited
1983
Stereospecific inhibition of PGH2-induced platelet aggregation by lipoxygenase products of icosaenoic acids.
M. Croset
,
M. Lagarde
Biochemical and Biophysical Research…
1983
Corpus ID: 34623641
Highly Cited
1983
Highly Cited
1983
Metabolism of arachidonic acid via the lipoxygenase pathway in human and murine glomeruli.
J. Sraer
,
M. Rigaud
,
M. Bens
,
H. Rabinovitch
,
R. Ardaillou
Journal of Biological Chemistry
1983
Corpus ID: 6786202
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