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Arachidonate 12-Lipoxygenase

Known as: Arachidonic Acid 12-Lipoxygenase, Arachidonate 12 Lipoxygenase, 12-Lipoxygenase, Arachidonate 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

12-15-lipoxygenaseAlox12b protein, mousehepoxilin synthase
ALOX12 geneALOX12B geneIn BloodProcess of secretion

Papers overview

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Highly Cited
2006
Highly Cited
2006
Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase Published, JLR Papers in Press, February 5, 2006.
Oxidized phospholipids stimulate endothelial cells to bind monocytes, but not neutrophils, an initiating event in atherogenesis… 
Highly Cited
1995
Highly Cited
1995
A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells. Evidence for upregulation by angiotensin II.
The lipoxygenase (LO) pathway has been implicated in leading to accelerated atherosclerosis. However, the precise type of LO… 
Highly Cited
1993
Highly Cited
1993
Molecular cloning of a 12-lipoxygenase cDNA from rat brain.
A cDNA encoding an arachidonate 12-lipoxygenase from rat brain was obtained by polymerase chain reaction cloning. Primers… 
Highly Cited
1993
Highly Cited
1993
Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases.
When arachidonate 12-lipoxygenase purified from porcine leukocytes was incubated aerobically with 1-palmitoyl-2-arachidonoyl-sn… 
Highly Cited
1991
Highly Cited
1991
Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction.
Highly Cited
1986
Highly Cited
1986
Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer.
Highly Cited
1986
Highly Cited
1986
Lipoxygenase in trout gill tissue acting on arachidonic, eicosapentaenoic and docosahexaenoic acids.
Review
1985
Review
1985
A review of possible roles of the platelet 12-lipoxygenase.
THE 12-LIPOXYGENASE ENZYME of platelets was the first lipoxygenase to be discovered in animal tissue,1 yet its physiologic… 
Highly Cited
1983
Highly Cited
1983
Stereospecific inhibition of PGH2-induced platelet aggregation by lipoxygenase products of icosaenoic acids.
Highly Cited
1983
Highly Cited
1983
Metabolism of arachidonic acid via the lipoxygenase pathway in human and murine glomeruli.
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