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Arachidonate 12-Lipoxygenase

Known as: Arachidonic Acid 12-Lipoxygenase, Arachidonate 12 Lipoxygenase, 12-Lipoxygenase, Arachidonate 
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a… Expand
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

12-15-lipoxygenaseAlox12b protein, mousehepoxilin synthase
ALOX12 geneALOX12B geneIn BloodProcess of secretion
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Papers overview

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Highly Cited
2007
Highly Cited
2007
TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2 and 12-Lipoxygenase
Histamine provokes itching and is a major skin disease complaint. Histamine is known to excite a subset of sensory neurons… Expand
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Highly Cited
2006
Highly Cited
2006
Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids
Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin… Expand
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Highly Cited
2003
Highly Cited
2003
Molecular Basis of Vitamin E Action
Vitamin E is a generic term for tocopherols and tocotrienols. This work is based on our striking evidence that, in neuronal cells… Expand
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Highly Cited
2002
Highly Cited
2002
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
Extensive studies have implicated the role of dietary fatty acids in prostatecancer progression. Platelet-type 12-Lipoxygenase… Expand
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Highly Cited
2000
Highly Cited
2000
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3.
Treatment of human artery wall cells with apolipoprotein A-I (apoA-I), but not apoA-II, with an apoA-I peptide mimetic, or with… Expand
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Highly Cited
2000
Highly Cited
2000
Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase.
Angiogenesis, the formation of new capillaries from preexisting blood vessels, is a multistep, highly orchestrated process… Expand
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Highly Cited
1997
Highly Cited
1997
A Role for 12-lipoxygenase in Nerve Cell Death Caused by Glutathione Depletion
An early and highly specific decrease in glutathione (GSH) in the substantia nigra is associated with Parkinson's disease, and… Expand
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Review
1995
Review
1995
Arachidonate 12-lipoxygenase.
In the last decade our laboratory has been investigating arachidonate 12-lipoxy-genase intensively and extensively.1.2 The enzyme… Expand
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Highly Cited
1992
Highly Cited
1992
Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
Isomers (alpha- and beta-) of boswellic acids (BAs), 11-keto-beta-BA and their acetyl derivatives were isolated from the gum… Expand
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Highly Cited
1989
Highly Cited
1989
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of… Expand
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