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Arachidonate 12-Lipoxygenase, 12R-Type

Known as: 12R-Lipoxygenase, 12R-LOX, EC 1.13.11.- 
Arachidonate 12-lipoxygenase, 12R-type (701 aa, ~80 kDa) is encoded by the human ALOX12B gene. This protein is involved in the oxidation of… 
National Institutes of Health

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11 relations
ALOX12B geneALOX12B wt AlleleArachidonic Acid Metabolism PathwayB-Lymphocytes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Inimese 12R-lipoksügenaasi ekspresseerimine pärmis Pichia pastoris.Expression of human 12R-lipoxygenase in the yeast Pichia pastoris.
2017
2017
Cloning, expression, purification of active recombinant human 12R-LOX enzyme and its inhibition by Acalypha indica extracts
12R-LOX over-expression has been reported in various pathologies such as psoriasis, proliferative dermatitis as well as pulmonary… 
2014
2014
A mouse organotypic tissue culture model for autosomal recessive congenital ichthyosis
Autosomal recessive congenital ichthyoses (ARCIs) are keratinization disorders caused by impaired skin barrier function… 
2012
2012
A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells
Eicosanoids are metabolites of arachidonic acid produced by cyclooxygenases (COXs) or lipoxygenases (LOXs). They mediate… 
2011
2011
Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of a 12R-LOX-chaperone complex.
Lipoxygenases are a family of nonheme iron-containing dioxygenases. An Escherichia coli expression system producing the bacterial… 
2009
2009
12R-Lipoxygenase deficient mouse skin models for autosomal recessive congenital ichthyosis
12R-lipoxygenase (12R-LOX) and epidermal LOX-3 (eLOX-3) are part of a recently identified eicosanoid pathway critically involved… 
2008
2008
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form
2004
2004
Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice.
Neonatal mice deficient in IkappaB-alpha, an inhibitor of the ubiquitous transcription factor NF-kappaB, develop severe and… 
2000
2000
Synthesis and applications of stereospecifically (3)H-labeled arachidonic acids as mechanistic probes for lipoxygenase and cyclooxygenase catalysis.
Stereospecifically (3)H-labeled substrates are useful tools in studying the mechanism of hydrogen abstractions involved in the… 
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