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Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand
The data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically TH17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases. Expand
Potential applications of ferulic acid from natural sources
FA exhibits wide variety of biological activities such as antioxidant, antiinflammatory, antimicrobial, antiallergic, hepatoprotective, anticarcinogenic, antithrombotic, increase sperm viability, antiviral and vasodilatory actions, metal chelation, modulation of enzyme activity, activation of transcriptional factors, gene expression and signal transduction. Expand
The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan
The results demonstrate that small molecules can be used to target the RORs for therapeutic intervention in metabolic and immune disorders and an excellent starting point for the development of ROR selective modulators. Expand
Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands*
It is demonstrated that 7-oxygenated sterols function as high affinity ligands for both RORα and RORγ by directly binding to their ligand-binding domains, modulating coactivator binding, and suppressing the transcriptional activity of the receptors. Expand
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.
The first selective synthetic RORα inverse agonist is identified, and this compound can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo, suggesting that ROR α inverse agonists may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics. Expand
Natural products – antifungal agents derived from plants
A series of molecules with antifungal activity against different strains of fungus have been found in plants, which are of great importance to humans. Expand
Inhibition of sulfate reducing bacteria in aquifer sediment by iron nanoparticles.
Microbial analysis revealed that the addition of Fe(0) and glycerol shifted the microbial community towards Desulfosporosinus sp. Expand
Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation
Novel synthetic compounds are described that have a unique mode of binding to PPARγ, completely lack classical transcriptional agonism and block the Cdk5-mediated phosphorylation in cultured adipocytes and in insulin-resistant mice, and one such compound, SR1664, has potent antidiabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PParγ drugs. Expand
Removal of chromium and nickel from aqueous solution in constructed wetland: Mass balance, adsorption–desorption and FTIR study
Abstract The present study was conducted to investigate the chromium and nickel removal from aqueous solutions in constructed wetland microcosms using Canna indica Lin. species. Effects of differentExpand
The removal of heavy metals in wetland microcosms: Effects of bed depth, plant species, and metal mobility
The present study deals with comparative evaluation of three different plants species, i.e. Canna indica L., Typha angustifolia L. and Cyperus alternifolius L. planted vertical constructed wetlandsExpand