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Arachidonate 12-Lipoxygenase, 12S-Type

Known as: EC 1.13.11.31, Platelet-Type Lipoxygenase 12, ALOX12 
Arachidonate 12-lipoxygenase, 12S-type (663 aa, ~76 kDa) is encoded by the human ALOX12 gene. This protein plays a role in both fatty acid oxidation… 
National Institutes of Health

Related topics

Related topics

10 relations
ALOX12 geneALOX12 wt AlleleArachidonic Acid Metabolism PathwayCytoplasm

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA
4‐Hydroxynonenal (HNE) is an important product of plasma membrane lipid peroxidation, which is a cause of cell and tissue injury… 
Highly Cited
2017
Highly Cited
2017
An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury
Hepatic ischemia–reperfusion (IR) injury is a common clinical issue lacking effective therapy and validated pharmacological… 
Highly Cited
2017
Highly Cited
2017
First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis
Objective— Adequate platelet reactivity is required for maintaining hemostasis. However, excessive platelet reactivity can also… 
Highly Cited
2017
Highly Cited
2017
Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexaenoic acid.
2015
2015
A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex
2014
2014
Hypoxic preconditioning protects rat hearts against ischemia–reperfusion injury via the arachidonate12-lipoxygenase/transient receptor potential vanilloid 1 pathway
Hypoxic preconditioning (HPC) protects rat hearts against ischemia–reperfusion (IR) injury. However, the role of transient… 
Highly Cited
2012
Highly Cited
2012
DNA hypomethylation at ALOX12 is associated with persistent wheezing in childhood.
RATIONALE Epigenetic changes may play a role in the occurrence of asthma-related phenotypes. OBJECTIVES To identify epigenetic… 
Highly Cited
2012
Highly Cited
2012
Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma
Abberrant DNA methylation is one of the hallmarks of cancerogenesis. Our study aims to delineate differential DNA methylation in… 
Highly Cited
2011
Highly Cited
2011
12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.
Highly Cited
2000
Highly Cited
2000
Diversity of mouse lipoxygenases: Identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern
By using reverse transcription-polymerase chain reaction technology (RT-PCR) and Northern blot analysis, the tissue-specific mRNA… 
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