Diversity of mouse lipoxygenases: Identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern

@article{Heidt2000DiversityOM,
  title={Diversity of mouse lipoxygenases: Identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern},
  author={Markus Heidt and Gerhard F{\"u}rstenberger and Sonja Vogel and Friedrich Marks and Peter Krieg},
  journal={Lipids},
  year={2000},
  volume={35},
  pages={701-707}
}
By using reverse transcription-polymerase chain reaction technology (RT-PCR) and Northern blot analysis, the tissue-specific mRNA expression patterns of seven mouse lipoxygenases (LOX)—including 5S-, 8S-, three isoforms of 12S-, 12R-LOX, and a LOX of an as-of-yet unknown spacificity, epidermis-type LOX-3 (e-LOX-3)—were investigated in NMRI mice. Among the various tissues tested epidermis and forestomach were found to express the broadest spectrum of LOX. With the exception of 5S-and platelet… CONTINUE READING

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