Apolipoprotein E4

Known as: Apolipoprotein E 4, Apo E epsilon 4, NP_000032.1:p.Cys130Arg 
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have… (More)
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Highly Cited
2004
Highly Cited
2004
Apolipoprotein E (apoE) is found in amyloid plaques and neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brains, but… (More)
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Highly Cited
2003
Highly Cited
2003
Apolipoprotein (apo) E4 increases the risk and accelerates the onset of Alzheimer's disease (AD). However, the underlying… (More)
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Review
2000
Review
2000
First recognized as a major determinant in lipoprotein metabolism and cardiovascular disease, apolipoprotein (apo) E has emerged… (More)
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Highly Cited
2000
Highly Cited
2000
Apolipoprotein E (apoE) alleles determine the age-adjusted relative risk (epsilon4 > epsilon3) for Alzheimer's disease (AD). ApoE… (More)
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Highly Cited
1995
Highly Cited
1995
Apolipoprotein E (apoE) is critical in the modulation of cholesterol and phospholipid transport between cells of different types… (More)
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Highly Cited
1994
Highly Cited
1994
Apolipoprotein E4 (apoE4), one of the three common isoforms of apoE, has been implicated in Alzheimer's disease. The effects of… (More)
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Highly Cited
1993
Highly Cited
1993
Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a neuropathological feature of Alzheimer… (More)
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Highly Cited
1993
Highly Cited
1993
Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile… (More)
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Highly Cited
1986
Highly Cited
1986
Apolipoprotein E (apoE) is important in modulating the catabolism of remnants of triglyceride-rich lipoprotein particles. It is a… (More)
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