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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- J. Lambert, C. Ibrahim-Verbaas, +179 authors P. Amouyel
- Biology, Medicine
- Nature Genetics
- 1 December 2013
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We… Expand
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide… Expand
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium… Expand
Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
The last comparison of prevalence figures of dementia across European studies was 10 years ago. Using studies conducted in the 1990s, the authors compare the age- and sex-specific prevalence of… Expand
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices.
- R. Insausti, K. Juottonen, +5 authors A. Pitkänen
- AJNR. American journal of neuroradiology
- 1 April 1998
PURPOSE Our purpose was to investigate the normal volumes of the human entorhinal, perirhinal, and temporopolar cortices on MR imaging studies using a customized program. METHODS We designed a… Expand
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
OBJECTIVE To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life. DESIGN Prospective, population based study. SETTING… Expand
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.
BACKGROUND Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular… Expand
Multi-Method Analysis of MRI Images in Early Diagnostics of Alzheimer's Disease
The role of structural brain magnetic resonance imaging (MRI) is becoming more and more emphasized in the early diagnostics of Alzheimer's disease (AD). This study aimed to assess the improvement in… Expand
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
- C. Pennanen, M. Kivipelto, S. Tuomainen, P. Hartikainen, H. Soininen
- Medicine, Psychology
- Neurobiology of Aging
- 1 March 2004
Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus and entorhinal cortex… Expand
Midlife vascular risk factors and late-life mild cognitive impairment
Objective: To evaluate the impact of midlife elevated serum cholesterol levels and blood pressure on the subsequent development of mild cognitive impairment (MCI) and to investigate the prevalence of… Expand