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Aphidicolin

Known as: 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-, Aphidicolin [Chemical/Ingredient] 
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (5)

18-nor-3-ketoaphidicolin3,16-diketoaphidicolan3-ketoaphidicolinaphidicolin glycinate

Broader (3)

AntimetabolitesAntiviral AgentsEnzyme Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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1988
1988
Aphidicolin synchronization of mouse L cells perturbs the relationship between cell killing and DNA double-strand breakage after X-irradiation.
Mouse L cells were synchronized in early S-phase by two 12 h incubations in medium containing aphidicolin (2 micrograms/ml… 
1985
1985
Effects of aphidicolin and/or 2',3'-dideoxythymidine on DNA repair induced in HeLa cells by four types of DNA-damaging agents.
The alkaline sucrose density gradient centrifugation method was modified to permit detection of 1 lesion/10(9) daltons of DNA… 
1984
1984
Aphidicolin and eukaryotic DNA synthesis.
Animal cells are endowed with two sites containing DNA: nucleus and mitochondrion. Plant cells are more complex in this respect… 
1984
1984
Completion of excision repair patches in human cell preparations: identification of a probable mode of excision and resynthesis.
Excision repair of u.v. damage in human fibroblasts is more sensitive to inhibitors of DNA polymerase alpha (cytosine arabinoside… 
1983
1983
Specific toxicity of aphidicolin to ultraviolet-irradiated excision proficient human skin fibroblasts.
Aphidicolin, a specific inhibitor of the eucaryotic alpha polymerase, has been employed to study the role of this enzyme in… 
1982
1982
Specificity and completeness of inhibition of DNA repair by novobiocin and aphidicolin.
Novobiocin and aphidicolin were both potent inhibitors of excision repair of u.v.-induced damage to DNA in human embryonic… 
1982
1982
Studies on differentiation without cleavage in Chaetopterus. Requirement for a definite number of DNA replication cycles shown by aphidicolin pulses.
  • Henri AlexandreB. De PetrocellisJ. Bracket
  • Differentiation; research in biological diversity
  • 1982
  • Corpus ID: 37076053
Aphidicolin, a powerful inhibitor of nuclear DNA replication, has been used to establish the level of polyploidisation required… 
1982
1982
Effects of aphidicolin on cell proliferation, repair of potentially lethal damage and repair of DNA strand breaks in Ehrlich ascites tumour cells exposed to X-rays.
The effects of aphidicolin, a specific inhibitor of DNA alpha-polymerase, have been studied on various cellular end-points and on… 
1982
1982
Arrest of chain growth of replicon-sized intermediates by aphidicolin during rat fibroblast cell chromosome replication.
The effect of aphidicolin, a specific inhibitor of DNA polymerase alpha, on size maturation of nascent DNA intermediates was… 
1981
1981
Studies on the inhibition of highly purified calf thymus 8S and 7.3S DNA polymerase alpha by aphidicolin
On activated DNA aphidicolin competitively inhibits the incorporation of dCMP by both calf thymus DNA polymerase alpha A2 and C…