Aphidicolin

Known as: 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-, Aphidicolin [Chemical/Ingredient] 
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Telomeres protect chromosome ends through the interaction of telomeric repeats with shelterin, a protein complex that represses… (More)
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Highly Cited
2005
Highly Cited
2005
The ATR-dependent DNA damage response pathway can respond to a diverse group of lesions as well as inhibitors of DNA replication… (More)
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Highly Cited
2003
Highly Cited
2003
Little is known about the quantitative contributions of nonhomologous end joining (NHEJ) and homologous recombination (HR) to DNA… (More)
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Highly Cited
1994
Highly Cited
1994
The human immunodeficiency virus productively infects and integrates into cells that have been arrested in the cell cycle with… (More)
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Highly Cited
1991
Highly Cited
1991
We have used immunofluorescence staining to study the subcellular distribution of cyclin A and B1 during the somatic cell cycle… (More)
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Highly Cited
1989
Highly Cited
1989
Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of… (More)
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Highly Cited
1988
Highly Cited
1988
We have microinjected aphidicolin, a specific inhibitor of DNA polymerase alpha, into syncytial Drosophila embryos. This… (More)
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Highly Cited
1984
Highly Cited
1984
Aphidicolin, a specific inhibitor of DNA polymerase α, is known to induce chromosomal aberrations. At concentrations that did not… (More)
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Highly Cited
1980
Highly Cited
1980
Both the inhibitory effect of aphidicolin on the replicative alpha-polymerase and the reversibility of its action in vivo… (More)
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Highly Cited
1978
Highly Cited
1978
THE study of the control of DNA synthesis would be helped if a variety of chemicals which influenced DNA synthesis in various… (More)
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