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Aphidicolin

Known as: 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-, Aphidicolin [Chemical/Ingredient] 
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (5)

18-nor-3-ketoaphidicolin3,16-diketoaphidicolan3-ketoaphidicolinaphidicolin glycinate

Broader (3)

AntimetabolitesAntiviral AgentsEnzyme Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1996
1996
Aphidicolin uncouples the chloroplast division cycle from the mitotic cycle in the unicellular red alga Cyanidioschyzon merolae.
The unicellular red alga Cyanidioschyzon merolae possesses one chloroplast, one mitochondrion, and one cell nucleus. Since the… 
Highly Cited
1996
Highly Cited
1996
A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints.
The constitutive fragile site at human chromosomal band 3p14.2, FRA3B, has been described as the most active common fragile site… 
Highly Cited
1990
Highly Cited
1990
Increased removal of DNA-bound platinum in a human ovarian cancer cell line resistant to cis-diamminedichloroplatinum(II).
A human ovarian cancer cell line resistant to cis-diamminedichloroplatinum(II) (DDP) (2780CP) was compared with its DDP-sensitive… 
1985
1985
Effects of aphidicolin and/or 2',3'-dideoxythymidine on DNA repair induced in HeLa cells by four types of DNA-damaging agents.
The alkaline sucrose density gradient centrifugation method was modified to permit detection of 1 lesion/10(9) daltons of DNA… 
1985
1985
Kinetics of DNA replication in C3H 10T1/2 cells synchronized by aphidicolin.
Aphidicolin is an inhibitor of DNA polymerase alpha and blocks nuclear DNA replication without interfering with mitochondrial DNA… 
1983
1983
Aphidicolin-induced endoreduplication in Chinese hamster cells.
Aphidicolin, a specific inhibitor of DNA polymerase alpha, was found to induce high frequencies of endoreduplication in Chinese… 
1982
1982
Specificity and completeness of inhibition of DNA repair by novobiocin and aphidicolin.
Novobiocin and aphidicolin were both potent inhibitors of excision repair of u.v.-induced damage to DNA in human embryonic… 
1982
1982
Effects of aphidicolin on cell proliferation, repair of potentially lethal damage and repair of DNA strand breaks in Ehrlich ascites tumour cells exposed to X-rays.
The effects of aphidicolin, a specific inhibitor of DNA alpha-polymerase, have been studied on various cellular end-points and on… 
Highly Cited
1981
Highly Cited
1981
Alteration of ribonucleotide reductase in aphidicolin-resistant mutants of mouse FM3A cells with associated resistance to arabinosyladenine and arabinosylcytosine
Aphidicolin-resistant mutants of mouse FM3A cells were isolated and characterized. Most of the mutants were of a type showing… 
1981
1981
Role of base damage in aberration formation: interaction of aphidicolin and x-rays
The base analog cytosine arabinoside (CA) is an inhibitor of DNA synthesis that is able to induce chromosomal aberrations not… 
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