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Apazone

Known as: 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, Apazone [Chemical/Ingredient] 
An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (4)

6-hydroxyazapropazoneProlixanRheumoxTolyprin

Broader (2)

Anti-Inflammatory Agents, Non-SteroidalUricosuric Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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2004
2004
An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species
SummaryA critical analysis has been performed of reports published on the incidence of gastro-intestinal (GI) side-effects found… 
1999
1999
Automated flow injection gradient technique for binding studies of micromolecules to proteins using potentiometric sensors: application to bovine serum albumin with anilinonaphthalenesulfonate probe…
An automated flow injection (FI) gradient technique is described for the binding study of the potentiometric probe 1-anilino-8… 
1995
1995
Effects of azapropazone on pain-related brain activity in human subjects.
1. The dose-related effects of azapropazone on (i) event-related and spontaneous EEG-activity and (ii) the subjects' pain ratings… 
1991
1991
Differential pathophysiology of bacterial translocation after thermal injury and sepsis.
Bacterial translocation (BT) occurs transiently after thermal injury and may result from an ischemic intestinal insult. To… 
1990
1990
The effect of prostaglandin synthetase inhibitors on human preovulatory follicular fluid prostaglandin, thromboxane, and leukotriene concentrations.
This study evaluates the eicosanoid concentration in luteinized unruptured follicles (LUFs) on the ovaries of patients who had… 
1987
1987
Comparative trial of azapropazone and indomethacin plus allopurinol in acute gout and hyperuricaemia.
This study compared the effects of azapropazone and indomethacin plus allopurinol in the management of acute gout and… 
1986
1986
Methotrexate toxicity precipitated by azapropazone
We report an episode of bone marrow hypoplasia following the administration of azapropazone to a patient stabilized on regular… 
1981
1981
Plasma protein binding of azapropazone in patients with kidney and liver disease.
1 The free fraction of azapropazone in the plasma of 37 healthy volunteers ranged from 0.0027 to 0.0070 (0.0044 +/- 0.0009, mean… 
1976
1976
A comparative study of azapropazone and ibuprofen in the treatment of osteoarthrosis of the knee
SummaryA double-blind crossover study in 41 patients with knee joint osteoarthrosis was carried out to compare the efficacy of… 
1971
1971
The action of azapropazone, oxyphenbutazone and phenylbutazone on lysosomes
Azapropazone, oxyphenbutazone and phenylbutazone have a stabilizing action on isolated lysosomes over a wide concentration range… 
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