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Apazone

Known as: 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, Apazone [Chemical/Ingredient] 
An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (4)

6-hydroxyazapropazoneProlixanRheumoxTolyprin

Broader (2)

Anti-Inflammatory Agents, Non-SteroidalUricosuric Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species
SummaryA critical analysis has been performed of reports published on the incidence of gastro-intestinal (GI) side-effects found… 
1999
1999
Automated flow injection gradient technique for binding studies of micromolecules to proteins using potentiometric sensors: application to bovine serum albumin with anilinonaphthalenesulfonate probe…
An automated flow injection (FI) gradient technique is described for the binding study of the potentiometric probe 1-anilino-8… 
1995
1995
Effects of azapropazone on pain-related brain activity in human subjects.
1. The dose-related effects of azapropazone on (i) event-related and spontaneous EEG-activity and (ii) the subjects' pain ratings… 
Highly Cited
1993
Highly Cited
1993
Study of interaction of carprofen and its enantiomers with human serum albumin--II. Stereoselective site-to-site displacement of carprofen by ibuprofen.
1991
1991
Differential pathophysiology of bacterial translocation after thermal injury and sepsis.
Bacterial translocation (BT) occurs transiently after thermal injury and may result from an ischemic intestinal insult. To… 
Review
1991
Review
1991
Dissociation Between the Antinociceptive and Anti-Inflammatory Effects of the Nonsteroidal Anti-Inflammatory Drugs
SummaryThe authors challenge the general view that the analgesic effect of the nonsteroidal anti-inflammatory drugs (NSAIDs) can… 
1990
1990
The effect of prostaglandin synthetase inhibitors on human preovulatory follicular fluid prostaglandin, thromboxane, and leukotriene concentrations.
This study evaluates the eicosanoid concentration in luteinized unruptured follicles (LUFs) on the ovaries of patients who had… 
1986
1986
Methotrexate toxicity precipitated by azapropazone
We report an episode of bone marrow hypoplasia following the administration of azapropazone to a patient stabilized on regular… 
1981
1981
Plasma protein binding of azapropazone in patients with kidney and liver disease.
1 The free fraction of azapropazone in the plasma of 37 healthy volunteers ranged from 0.0027 to 0.0070 (0.0044 +/- 0.0009, mean… 
1971
1971
The action of azapropazone, oxyphenbutazone and phenylbutazone on lysosomes
Azapropazone, oxyphenbutazone and phenylbutazone have a stabilizing action on isolated lysosomes over a wide concentration range… 
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