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Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
TLDR
Data support the concept that oxidative stress may contribute not only to endothelial dysfunction but also to coronary artery disease activity, and predict the risk of cardiovascular events in patients with coronary arteries disease.
Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
TLDR
Given its proinflammatory properties, MPO may serve as both a marker and mediator of vascular inflammation and further points toward the significance of PMN activation in the pathophysiology of ACS.
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
TLDR
In vivo and in vitro studies have indicated a crucial role of the diacylglycerol-protein kinase C (PKC) pathway in mediatingHyperglycemia is the major causal factor in the development of endothelial dysfunction in patients with diabetes mellitus.
The Registry of the German Competence NETwork on Atrial Fibrillation: patient characteristics and initial management
TLDR
The use of oral anticoagulation in eligible patients was among the highest reported, whereas decisions on rate and rhythm control often do not follow current recommendations.
Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling
TLDR
It is concluded that angiotensin II-induced increases in the activity and the expression of NAD(P)H oxidase are at least in part PKC-dependent and may trigger NOS III uncoupling, leading to impaired NO/cGMP signaling and to endothelial dysfunction in this animal model.
Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I.
TLDR
Bedside tests for cardiac-specific troponins are highly sensitive for the early detection of myocardial-cell injury in acute coronary syndromes and allow rapid and safe discharge of patients with an episode of acute chest pain from the emergency room.
Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase.
TLDR
The concept that in addition to the free radical burden of cigarette smoke, a dysfunctional NOS III due to BH4 depletion may contribute at least in part to endothelial dysfunction in chronic smokers is supported.
Outcome parameters for trials in atrial fibrillation: executive summary.
TLDR
An expert consensus of required outcome parameters in seven relevant outcome domains, namely death, stroke, symptoms and quality of life, rhythm, left ventricular function, cost, and emerging outcome parameters, are described.
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
TLDR
Results reveal that binding of MPO to CD11b/CD18 integrins stimulates PMN signaling pathways to induce PMN activation in a mechanism independent of MPo catalytic activity.
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