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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential… Expand
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
- J. Kirchheiner, H. Schmidt, +4 authors J. Brockmöller
- Biology, Medicine
- The Pharmacogenomics Journal
- 1 August 2007
Codeine is an analgesic drug acting on μ-opiate receptors predominantly via its metabolite morphine, which is formed almost exclusively by the genetically polymorphic enzyme cytochrome P450 2D6… Expand
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.
BACKGROUND & AIMS Genetic variation in the interleukin 28B (IL28B) gene has been associated with the response to interferon-alfa/ribavirin therapy in hepatitis C virus (HCV) genotype 1-infected… Expand
Ziconotide for treatment of severe chronic pain
Pharmacological management of severe chronic pain is difficult to achieve with currently available analgesic drugs, and remains a large unmet therapeutic need. The synthetic peptide ziconotide has… Expand
Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers
- C. Skarke, J. Darimont, H. Schmidt, G. Geisslinger, J. Lötsch
- Clinical pharmacology and therapeutics
- 1 January 2003
Our objective was to quantify the extent and time course of the effects of morphine‐6‐glucuronide and morphine on pain threshold, pain tolerance, pupil diameter, and side effects.
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.
- J. Lötsch, C. Skarke, S. Grösch, J. Darimont, H. Schmidt, G. Geisslinger
- Biology, Medicine
Large individual differences in the clinical response to morphine therapy have been known for a long time by clinicians. The recent advances in genomic research encourage the search for… Expand
Olfactory function in mild cognitive impairment and Alzheimer's disease: an investigation using psychophysical and electrophysiological techniques.
- Jürgen M Peters, T. Hummel, T. Kratzsch, J. Lötsch, C. Skarke, L. Froelich
- Medicine, Psychology
- The American journal of psychiatry
- 1 November 2003
OBJECTIVE To clarify the olfactory deficit hypothesis regarding Alzheimer's disease, the authors compared olfactory function in patients with Alzheimer's disease, subjects with mild cognitive… Expand
Quick Discrimination of Adelta and C Fiber Mediated Pain Based on Three Verbal Descriptors
Background Aδ and C fibers are the major pain-conducting nerve fibers, activate only partly the same brain areas, and are differently involved in pain syndromes. Whether a stimulus excites… Expand
Are mu-opioid receptor polymorphisms important for clinical opioid therapy?
Mutations in the mu-opioid receptor--the primary site of action of opioid analgesics--are candidates for the variability of clinical opioid effects. This has been substantiated by recent advances in… Expand
Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection.
BACKGROUND & AIMS Recent studies have described a major impact of genetic variations near the IL28B gene on the natural course and outcome of antiviral therapy in chronic hepatitis C. We therefore,… Expand