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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
- I. Tegeder, M. Costigan, C. Woolf
- Biology, MedicineNature Medicine
- 1 November 2006
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential…
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
- J. Kirchheiner, H. Schmidt, J. Brockmöller
- Biology, MedicineThe Pharmacogenomics Journal
- 1 August 2007
TLDR
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.
- C. Sarrazin, S. Susser, T. Berg
- Biology, MedicineJournal of hepatology
- 1 March 2011
Ziconotide for treatment of severe chronic pain
- A. Schmidtko, J. Lötsch, R. Freynhagen, G. Geisslinger
- Biology, MedicineThe Lancet
- 1 May 2010
Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers
- C. Skarke, J. Darimont, H. Schmidt, G. Geisslinger, J. Lötsch
- Biology, MedicineClinical pharmacology and therapeutics
- 1 January 2003
Our objective was to quantify the extent and time course of the effects of morphine‐6‐glucuronide and morphine on pain threshold, pain tolerance, pupil diameter, and side effects.
Olfactory function in mild cognitive impairment and Alzheimer's disease: an investigation using psychophysical and electrophysiological techniques.
- J. Peters, T. Hummel, T. Kratzsch, J. Lötsch, C. Skarke, L. Frölich
- Psychology, BiologyThe American journal of psychiatry
- 1 November 2003
TLDR
Quick Discrimination of Adelta and C Fiber Mediated Pain Based on Three Verbal Descriptors
- F. Beissner, Amadeus Brandau, J. Lötsch
- Medicine, BiologyPloS one
- 23 September 2010
TLDR
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.
- J. Lötsch, C. Skarke, S. Grösch, J. Darimont, H. Schmidt, G. Geisslinger
- Biology, MedicinePharmacogenetics
- 2002
TLDR
Are mu-opioid receptor polymorphisms important for clinical opioid therapy?
- J. Lötsch, G. Geisslinger
- Biology, MedicineTrends in molecular medicine
- 1 February 2005
Pharmacokinetics of Opioids in Liver Disease
- I. Tegeder, J. Lötsch, G. Geisslinger
- Medicine, BiologyClinical pharmacokinetics
- 1 July 1999
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