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Anti-Nectin 4 Antibody-Drug Conjugate ASG-22CE

Known as: ASG-22CE, Anti-Nectin 4 ADC ASG-22CE 
An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting the cell adhesion molecule nectin-4 and conjugated to the… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss
Stress impairs cognition via corticotropin-releasing hormone receptor 1 (CRHR1), but the molecular link between abnormal CRHR1… 
Highly Cited
2009
Highly Cited
2009
The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction
Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin–afadin complex also… 
2009
2009
Involvement of afadin in the formation and remodeling of synapses in the hippocampus.
Highly Cited
2008
Highly Cited
2008
Involvement of the nectin-afadin complex in PDGF-induced cell survival
The nectin-afadin complex is involved in the formation of cell-cell junctions, such as adherens junctions (AJs) and tight… 
Highly Cited
2004
Highly Cited
2004
Involvement of LMO7 in the Association of Two Cell-Cell Adhesion Molecules, Nectin and E-cadherin, through Afadin and α-Actinin in Epithelial Cells*
Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules that are involved in formation of cadherin-based… 
Highly Cited
2004
Highly Cited
2004
Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells
Nectins, Ca2+‐independent immunoglobulin‐like cell adhesion molecules (CAMs), first form cell‐cell adhesion where cadherins are… 
Highly Cited
2003
Highly Cited
2003
Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E‐cadherin‐based cell‐cell adhesion
Background: Nectin is a Ca2+‐independent immunoglobulin‐like cell‐cell adhesion molecule at the E‐cadherin‐based cell‐cell… 
2003
2003
Nectin‐dependent localization of ZO‐1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus
Nectin and afadin constitute a novel intercellular adhesion system that organizes adherens junctions in cooperation with the… 
Highly Cited
2002
Highly Cited
2002
Role of nectin in organization of tight junctions in epithelial cells
Background In polarized epithelial cells, cell‐cell adhesion forms specialized membrane structures comprised of claudin‐based… 
2002
2002
Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions
ABSTRACT Nectin-1 and nectin-2 are related molecules that can function with different specificities as entry receptors for… 
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