M. Peifer

Publications173
h-index70
Citations17,428
Highly Influential Citations1,068
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Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF
The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with beta-catenin and are hypothesized to mediate Wingless/Wnt signaling. We have cloned… Expand
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Negative regulation of Armadillo, a Wingless effector in Drosophila.
Drosophila Armadillo and its vertebrate homolog beta-catenin play essential roles both in the transduction of Wingless/Wnt cell-cell signals and in the function of cell-cell adherens junctions.… Expand
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The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
Cell polarity is critical for epithelial structure and function. Adherens junctions (AJs) often direct this polarity, but we previously found that Bazooka (Baz) acts upstream of AJs as epithelial… Expand
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Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.
The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal… Expand
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Drosophila Tcf and Groucho interact to repress Wingless signalling activity
Wingless/Wnt signalling directs cell-fate choices during embryonic development,. Inappropriate reactivation of the pathway causes cancer. In Drosophila, signal transduction from Wingless stabilizes… Expand
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Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila
Adherens junctions (AJs) are thought to be key landmarks for establishing epithelial cell polarity, but the origin of epithelial polarity in Drosophila remains unclear. Thus, we examined epithelial… Expand
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An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling
Armadillo, the Drosophila homologue of vertebrate beta-catenin, plays a pivotal role both in Wingless signaling and in assembly of adherens junctions. We performed the first in vivo… Expand
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The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction
Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin–afadin complex also localizes to AJs and links to the cytoskeleton. Mammalian afadin has been… Expand
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wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo.
wingless/wnt-1 signaling directs cell fate during development. Genetic analysis in Drosophila identified genes that may encode components of the wingless signal transduction system. Drosophila… Expand
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A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis.
The epithelial sheet is a structural unit common to many tissues. Its organization appears to depend on the function of the multi-protein complexes that form adherens junctions. Elegant cell… Expand
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