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Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family
We identified and cloned a cellular mediator of herpes simplex virus (HSV) entry. Hamster and swine cells resistant to viral entry became susceptible upon expression of a human cDNA encoding this… Expand
Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.
- R. J. Geraghty, C. Krummenacher, G. Cohen, R. Eisenberg, P. Spear
- Biology, Medicine
- 5 June 1998
A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine… Expand
LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.
Herpes simplex virus (HSV) 1 and 2 infect activated T lymphocytes by attachment of the HSV envelope glycoprotein D (gD) to the cellular herpesvirus entry mediator (HVEM), an orphan member of the… Expand
Initial interaction of herpes simplex virus with cells is binding to heparan sulfate.
We have shown that cell surface heparan sulfate serves as the initial receptor for both serotypes of herpes simplex virus (HSV). We found that virions could bind to heparin, a related… Expand
A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient for… Expand
Herpesvirus Entry: an Update
Herpesviruses engage multiple receptors during viral entry. Some are considered binding receptors only, in that engagement with these receptors may be reversible and may serve to concentrate virus on… Expand
Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate.
To characterize cellular factors required for herpes simplex virus type 1 (HSV-1)-induced cell fusion, we used an efficient and quantitative assay relying on expression of HSV-1 glycoproteins in… Expand
Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans
- M. T. Shieh, D. WuDunn, R. Montgomery, J. Esko, P. Spear
- Biology, Medicine
- The Journal of cell biology
- 1 March 1992
The role of cell surface heparan sulfate in herpes simplex virus (HSV) infection was investigated using CHO cell mutants defective in various aspects of glycosaminoglycan synthesis. Binding of… Expand
Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry.
Glycosaminoglycan chains on cell surface proteoglycans provide initial docking sites for the binding to eukaryotic cells of various viruses and other microorganisms. The ubiquitously expressed… Expand
A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.
Certain mutant strains of herpes simplex virus type 1 (HSV-1) are unable to infect cells in which entry is dependent on HVEM, the previously described herpesvirus entry mediator designated here as… Expand