The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction

@inproceedings{Sawyer2009TheDA,
  title={The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction},
  author={Jessica K. Sawyer and Nathan J. Harris and Kevin C Slep and Ulrike Gaul and Mark Peifer},
  booktitle={The Journal of cell biology},
  year={2009}
}
Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin-afadin complex also localizes to AJs and links to the cytoskeleton. Mammalian afadin has been suggested to be essential for adhesion and polarity establishment, but its mechanism of action is unclear. In contrast, Drosophila melanogaster's afadin homologue Canoe (Cno) has suggested roles in signal transduction during morphogenesis. We completely removed Cno from embryos, testing these… CONTINUE READING
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