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Angiostatins

Known as: ANGIOSTATIN, Angiostatins [Chemical/Ingredient] 
Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (3)

Angiogenesis InhibitorsAntineoplastic AgentsPlasminogen
AngiostatIn BloodPLG geneProcess of secretion

Narrower (1)

angiostatin, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome.
Highly Cited
2006
Highly Cited
2006
Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase.
Angiostatin, a proteolytic fragment of plasminogen, is a potent angiogenesis inhibitor able to suppress tumor growth and… 
Highly Cited
2006
Highly Cited
2006
Therapeutic potential of angiostatin in diabetic nephropathy.
Angiostatin is a proteolytic fragment of plasminogen and a potent angiogenic inhibitor. Previous studies have shown that… 
Review
2004
Review
2004
Angiostatin and Angiostatin-related Proteins
The study of angiogenesis, and the promise of angiogenesis inhibition as a means of cancer therapy, has dramatically accelerated… 
Highly Cited
2003
Highly Cited
2003
The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin.
Recently, we demonstrated that the designed peptide anginex displays potent antiangiogenic activity. The aim of the present study… 
Highly Cited
2002
Highly Cited
2002
Angiostatin gene transfer as an effective treatment strategy in murine collagen-induced arthritis.
OBJECTIVE To determine the efficacy of local therapy with human angiostatin gene in murine collagen-induced arthritis (CIA… 
Highly Cited
2002
Highly Cited
2002
Differential effects of angiostatin, endostatin and interferon-α1 gene transfer on in vivo growth of human breast cancer cells
The administration of different angiogenesis inhibitors by gene transfer has been shown to result in inhibition of tumor growth… 
Highly Cited
2000
Highly Cited
2000
Angiostatin Generation by Cathepsin D Secreted by Human Prostate Carcinoma Cells*
Angiostatin, a potent endogenous inhibitor of angiogenesis, is generated by cancer-mediated proteolysis of plasminogen. The… 
Highly Cited
1999
Highly Cited
1999
Angiostatin Formation Involves Disulfide Bond Reduction and Proteolysis in Kringle 5 of Plasmin*
Plasmin is processed in the conditioned medium of HT1080 fibrosarcoma cells producing fragments with the domain structures of the… 
Highly Cited
1998
Highly Cited
1998
Angiostatin-mediated Suppression of Cancer Metastases by Primary Neoplasms Engineered to Produce Granulocyte/Macrophage Colony–stimulating Factor
We determined whether tumor cells consistently generating granulocyte/macrophage colony– stimulating factor (GM-CSF) can recruit… 
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