Angiostatins

Known as: ANGIOSTATIN, Angiostatins [Chemical/Ingredient] 
Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS… (More)
National Institutes of Health

Papers overview

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Review
2002
Review
2002
Angiogenesis is required for invasive tumor growth and metastasis and constitutes an important point in the control of cancer… (More)
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Highly Cited
2001
Highly Cited
2001
Angiostatin blocks tumor angiogenesis in vivo, almost certainly through its demonstrated ability to block endothelial cell… (More)
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Highly Cited
2000
Highly Cited
2000
Integrin alpha1beta1 is a collagen receptor abundantly expressed on microvascular endothelial cells. As well as being the only… (More)
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Highly Cited
1998
Highly Cited
1998
Angiostatin is a circulating inhibitor of angiogenesis generated by proteolytic cleavage of plasminogen. In this study we have… (More)
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Highly Cited
1998
Highly Cited
1998
Angiostatin, a cleavage product of plasminogen, has been shown to inhibit endothelial cell proliferation and metastatic tumor… (More)
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Highly Cited
1998
Highly Cited
1998
Angiostatin, a fragment of plasminogen, has been identified and characterized as an endogenous inhibitor of neovascularization… (More)
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Highly Cited
1997
Highly Cited
1997
We previously identified the angiogenesis inhibitor angiostatin. Using a similar strategy, we have identified endostatin, an… (More)
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Highly Cited
1997
Highly Cited
1997
To determine the mechanism responsible for the in vivo production of angiostatin that inhibits growth and metastasis in Lewis… (More)
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Highly Cited
1996
Highly Cited
1996
There is now considerable direct evidence that tumor growth is angiogenesis–dependent1–4. The most compelling evidence is based… (More)
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Review
1995
Review
1995
Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis… (More)
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