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Exogenous Tumor Necrosis Factor-Alpha Mimics Nucleus Pulposus-Induced Neuropathology: Molecular, Histologic, and Behavioral Comparisons in Rats
Study Design. This study tested the hypothesis that the 17-kDa form of tumor necrosis factor-alpha is the pathophysiologic agent expressed by herniated nucleus pulposus in vivo that is primarily… Expand
Lysis of adhesions and epidural injection of steroid/local anaesthetic during epiduroscopy potentially alleviate low back and leg pain in elderly patients with lumbar spinal stenosis.
- T. Igarashi, Y. Hirabayashi, N. Seo, K. Saitoh, H. Fukuda, H. Suzuki
- British journal of anaesthesia
- 1 August 2004
BACKGROUND Lumbar spinal stenosis causes various forms of back or leg pain, and is recognized with increasing frequency in elderly patients whose physical status is not always suitable for surgery.… Expand
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury.
- H. Oharazawa, T. Igarashi, +6 authors I. Ohsawa
- Chemistry, Medicine
- Investigative ophthalmology & visual science
PURPOSE Retinal ischemia-reperfusion (I/R) injury by transient elevation of intraocular pressure (IOP) is known to induce neuronal damage through the generation of reactive oxygen species. Study… Expand
Novel nonsense mutation in the Na+/HCO3- cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma.
- T. Igarashi, J. Inatomi, +9 authors H. Endou
- Medicine, Biology
- Journal of the American Society of Nephrology…
- 1 April 2001
Permanent isolated proximal renal tubular acidosis (pRTA) with ocular abnormalities is a systemic disease involving short stature, isolated pRTA, mental retardation, and ocular abnormalities. Kidney… Expand
Reactive gliosis of astrocytes and Müller glial cells in retina of POMGnT1-deficient mice
- Hisatomo Takahashi, Hironori Kanesaki, T. Igarashi, Shuhei Kameya, H. Takahashi
- Biology, Medicine
- Molecular and Cellular Neuroscience
- 1 June 2011
Protein O-linked mannose beta1, 2-N-acetylglucosaminyltransferase 1 (POMGnT1) is an enzyme that catalyzes the transfer of N-acetylglucosamine to O-mannose of glycoproteins. Alpha-dystroglycan, a… Expand
Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent'sJapan disease.
BACKGROUND The annual urinary screening of Japanese children above three years of age has identified a progressive renal tubular disorder characterized by low molecular weight proteinuria,… Expand
Hypercalciuria and nephrocalcinosis in patients with idiopathic low-molecular-weight proteinuria in Japan: is the disease identical to Dent's disease in United Kingdom?
Idiopathic low-molecular-weight (LMW) proteinuria is a newly described renal disease in Japan and Italy. We report on 7 patients who manifested bilateral or unilateral nephrocalcinosis, as… Expand
Correlation between dry eye and rheumatoid arthritis activity.
- Miho Fujita, T. Igarashi, Toshiyuki Kurai, M. Sakane, Shinichi Yoshino, H. Takahashi
- American journal of ophthalmology
- 1 November 2005
PURPOSE To evaluate the incidence of dry eye in rheumatoid arthritis (RA) patients with or without Sjögren syndrome (SS), and to investigate the correlation between dry eye and RA activity. DESIGN… Expand
Phacoemulsification associated corneal damage evaluated by corneal volume.
- H. Suzuki, H. Takahashi, J. Hori, M. Hiraoka, T. Igarashi, T. Shiwa
- American journal of ophthalmology
- 1 September 2006
PURPOSE To determine the usefulness of the Pentacam corneal volume assay in the assessment of corneal endothelial damage caused by phacoemulsification and aspiration (PEA). DESIGN Prospective,… Expand
Application of Nucleus Pulposus to the Nerve Root Simultaneously Reduces Blood Flow in Dorsal Root Ganglion and Corresponding Hindpaw in the Rat
Study Design. An experimental study to clarify the effects of nucleus pulposus on blood flow in the dorsal root ganglion and hindpaws. Objectives. To investigate the effects of application of nucleus… Expand