angiostatin, human

Known as: Angiostatin, Kringles 1-4 of Plasminogen, PLG 
A protein normally made by the body. It can also be made in the laboratory, and is being studied in the treatment of cancer. Angiostatin may prevent… (More)

Topic mentions per year

Topic mentions per year

1973-2018
0204019732018

Papers overview

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Highly Cited
2001
Highly Cited
2001
Angiostatin, a circulating inhibitor of angiogenesis, was identified by its ability to maintain dormancy of established… (More)
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Highly Cited
2001
Highly Cited
2001
Angiostatin blocks tumor angiogenesis in vivo, almost certainly through its demonstrated ability to block endothelial cell… (More)
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Highly Cited
2000
Highly Cited
2000
Integrin alpha1beta1 is a collagen receptor abundantly expressed on microvascular endothelial cells. As well as being the only… (More)
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Highly Cited
1999
Highly Cited
1999
Angiostatin, a proteolytic fragment of plasminogen, is a potent antagonist of angiogenesis and an inhibitor of endothelial cell… (More)
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Highly Cited
1998
Highly Cited
1998
Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression. Angiostatin, a… (More)
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Highly Cited
1998
Highly Cited
1998
Angiostatin, a cleavage product of plasminogen, has been shown to inhibit endothelial cell proliferation and metastatic tumor… (More)
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Highly Cited
1998
Highly Cited
1998
Angiostatin, a fragment of plasminogen, has been identified and characterized as an endogenous inhibitor of neovascularization… (More)
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Highly Cited
1997
Highly Cited
1997
To determine the mechanism responsible for the in vivo production of angiostatin that inhibits growth and metastasis in Lewis… (More)
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Highly Cited
1996
Highly Cited
1996
There is now considerable direct evidence that tumor growth is angiogenesis–dependent1–4. The most compelling evidence is based… (More)
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Highly Cited
1994
Highly Cited
1994
The phenomenon of inhibition of tumor growth by tumor mass has been repeatedly studied, but without elucidation of a satisfactory… (More)
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