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Aminopterin

Known as: Aminopteroylglutamic Acid, N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}benzoyl)glutamic acid, 4-Amino-PGA 
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate… Expand
National Institutes of Health

Related topics

Related topics

36 relations

Narrower (23)

10-deazaaminopterin10-propargyl-10-deazaaminopterin10-propargylaminopterin11-oxahomoaminopterin
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Aminopterin SodiumIn BloodNCIt Antineoplastic Agent Terminologyagonists
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Broader (4)

Antineoplastic AgentsFolic Acid AntagonistsPesticidesPteridines

Papers overview

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Highly Cited
2012
Highly Cited
2012
Polymersomes in polymersomes: multiple loading and permeability control.
With such a compartmentalized structure, a mol-ecule encapsulated in the inner liposome, would have topermeate through two… Expand
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Highly Cited
2008
Highly Cited
2008
Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation.
In the study, chitosan (CS) was conjugated with trimethyl groups for the synthesis of N-trimethyl chitosan (TMC) polymers with… Expand
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Review
1997
Review
1997
Fifty years of studies of the biology and therapy of childhood leukemia.
SINCE CHEMOTHERAPY beginnings 50 years ago by Farber and his colleagues, childhood leukemia treatment has been one of the most… Expand
  • table 1
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Highly Cited
1992
Highly Cited
1992
Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons
We have developed a series of mouse‐mouse neural hybrid cell lines by fusing the aminopterin‐sensitive neuroblastoma N18TG2 with… Expand
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Highly Cited
1989
Highly Cited
1989
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.
Generation of nitric oxide (NO.), an autacoid with vasorelaxant and cytotoxic properties, requires at least three cytosolic… Expand
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Review
1980
Review
1980
Production of monoclonal antibodies: strategy and tactics.
A myeloma line has been developed which produces no globulin chains of its own, has a duplication of 8.7 h, fuses effectively… Expand
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Highly Cited
1979
Highly Cited
1979
Monoclonal antibody to a plasma membrane antigen of neurons.
Fusion of spleen cells from a mouse immunized with chicken embryo retina cells with clonal mouse myeloma cells yielded a… Expand
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Highly Cited
1975
Highly Cited
1975
Chemical induction of sperm abnormalities in mice.
  • A. Wyrobek, W. Bruce
  • Proceedings of the National Academy of Sciences…
  • 1975
    • Corpus ID: 36406213
The sperm of (C57BL X C3H)F1 mice were examined 1, 4, and 10 weeks after a subacute treatment with one of 25 chemicals at two or… Expand
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Highly Cited
1952
Highly Cited
1952
Therapeutic abortions with a folic acid antagonist, 4-aminopteroylglutamic acid (4-amino P.G.A) administered by the oral route.
  • J. Thiersch
  • American journal of obstetrics and gynecology
  • 1952
    • Corpus ID: 32085389
1. Oral doses of 6 to 12 mg. 4-amino P. G. A. induced fetal death in the first trimester of pregnancy followed by spontaneous… Expand
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Highly Cited
1948
Highly Cited
1948
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia… Expand
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