Skip to search formSkip to main contentSkip to account menu

Aminopterin

Known as: Aminopteroylglutamic Acid, N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}benzoyl)glutamic acid, 4-Amino-PGA 
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate… 
National Institutes of Health

Related topics

Related topics

36 relations

Narrower (23)

10-deazaaminopterin10-propargyl-10-deazaaminopterin10-propargylaminopterin11-oxahomoaminopterin
Aminopterin SodiumIn BloodNCIt Antineoplastic Agent Terminologyagonists

Broader (4)

Antineoplastic AgentsFolic Acid AntagonistsPesticidesPteridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation.
In the study, chitosan (CS) was conjugated with trimethyl groups for the synthesis of N-trimethyl chitosan (TMC) polymers with… 
Highly Cited
1991
Highly Cited
1991
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.
Highly Cited
1985
Highly Cited
1985
Drug‐induced hepatitis associated with anticytoplasmic organelle autoantibodies
A study from five hepatology units documenting 157 cases of drug‐induced hepatitis and a second study from a laboratory of… 
Highly Cited
1984
Highly Cited
1984
Characterization of a monoclonal antibody to the rat liver glucocorticoid receptor.
The rat liver glucocorticoid receptor was partially purified and used to immunize a BALB/c mouse whose splenic lymphocytes were… 
Highly Cited
1984
Highly Cited
1984
Gene transfer, expression, and molecular cloning of the human transferrin receptor gene
Highly Cited
1984
Highly Cited
1984
Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).
Hemophilia B is an X-linked disease caused by a functional deficiency in coagulation factor IX. A cDNA clone corresponding to… 
Highly Cited
1984
Highly Cited
1984
A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates.
Highly Cited
1974
Highly Cited
1974
A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors
Abstract A neuroblastoma × glioma hybrid cell line with well-developed neural properties was found that has high-affinity… 
Highly Cited
1956
Highly Cited
1956
The cytotoxic action of carcinolytic agents in tissue culture.
Highly Cited
1950
Highly Cited
1950
On the Mechanism of Action of Aminopterin.∗
Summary Rat liver slices form from synthetic folic acid (PGA) a factor (CF) utilized for growth by Leuconostoc citrovorum; this… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)