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Aminopterin

Known as: Aminopteroylglutamic Acid, N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}benzoyl)glutamic acid, 4-Amino-PGA 
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
With such a compartmentalized structure, a mol-ecule encapsulated in the inner liposome, would have topermeate through two… Expand
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Highly Cited
2008
Highly Cited
2008
In the study, chitosan (CS) was conjugated with trimethyl groups for the synthesis of N-trimethyl chitosan (TMC) polymers with… Expand
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Review
1997
Review
1997
SINCE CHEMOTHERAPY beginnings 50 years ago by Farber and his colleagues, childhood leukemia treatment has been one of the most… Expand
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Highly Cited
1992
Highly Cited
1992
We have developed a series of mouse‐mouse neural hybrid cell lines by fusing the aminopterin‐sensitive neuroblastoma N18TG2 with… Expand
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Highly Cited
1989
Highly Cited
1989
Generation of nitric oxide (NO.), an autacoid with vasorelaxant and cytotoxic properties, requires at least three cytosolic… Expand
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Review
1980
Review
1980
A myeloma line has been developed which produces no globulin chains of its own, has a duplication of 8.7 h, fuses effectively… Expand
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Highly Cited
1979
Highly Cited
1979
Fusion of spleen cells from a mouse immunized with chicken embryo retina cells with clonal mouse myeloma cells yielded a… Expand
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Highly Cited
1975
Highly Cited
1975
  • A. Wyrobek, W. Bruce
  • Proceedings of the National Academy of Sciences…
  • 1975
  • Corpus ID: 36406213
The sperm of (C57BL X C3H)F1 mice were examined 1, 4, and 10 weeks after a subacute treatment with one of 25 chemicals at two or… Expand
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Highly Cited
1952
Highly Cited
1952
  • J. Thiersch
  • American journal of obstetrics and gynecology
  • 1952
  • Corpus ID: 32085389
1. Oral doses of 6 to 12 mg. 4-amino P. G. A. induced fetal death in the first trimester of pregnancy followed by spontaneous… Expand
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Highly Cited
1948
Highly Cited
1948
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia… Expand
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