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Aminopterin

Known as: Aminopteroylglutamic Acid, N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}benzoyl)glutamic acid, 4-Amino-PGA 
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate… 
National Institutes of Health

Related topics

Related topics

36 relations

Narrower (23)

10-deazaaminopterin10-propargyl-10-deazaaminopterin10-propargylaminopterin11-oxahomoaminopterin
Aminopterin SodiumIn BloodNCIt Antineoplastic Agent Terminologyagonists

Broader (4)

Antineoplastic AgentsFolic Acid AntagonistsPesticidesPteridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1988
1988
Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
In contrast to methotrexate (MTX) and aminopterin (AMT), the 8-deaza analogues of these antifolates are not substrates for rabbit… 
1977
1977
Induction of deoxycytidine deaminase activity in mammalian cell lines by infection with herpes simplex virus type 1.
Herpes simplex virus type 1 induces deoxycytidine deaminase (cytidine/deoxycytidine aminohydrolase, EC 3.5.4.5) activity when it… 
Highly Cited
1976
Highly Cited
1976
Teratogenicity studies with methotrexate, aminopterin, and acetylsalicylic acid in domestic cats.
Pregnancy was timed in cats following induced ovulation. Methotrexate, (0.5 mg/kg), aminopterin, (0.1 mg/kg), and acetylsalicylic… 
Highly Cited
1972
Highly Cited
1972
Cytological mapping of human X-linked genes by use of somatic cell hybrids involving an X-autosome translocation (mouse-hamster-human X-linked markers).
Man-mouse and man-Syrian hamster somatic hybrid cell lines were prepared by fusion of mouse A9 or hamster TG2 cells, which are… 
Highly Cited
1972
Highly Cited
1972
Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell.
Comparison was made of the uptake in L1210 leukemia cells of the agents aminopterin, methotrexate, and the quinazoline antifolate… 
1966
1966
Permeability of Ehrlich ascites cells to folic acid, aminopterin, and amethopterin.
The uptake of folic acid and the folic analogs by suspensions of Ehrlich ascites cells consisted of a rapid reversible binding to… 
1961
1961
Methotrexate vs. aminopterin for psoriasis.
The value of antimetabolites for psoriasis was first observed by Gubner. 1 He pointed out that the suppressive effects of… 
Review
1956
Review
1956
The control of reproduction in rats with the aid of antimetabolites and early experiences with antimetabolites as abortifacient agents in man.
In 1948, Thiersch and Philips observed that two or three doses of the potent folic acid antagonist 4-Amino-PGA when given in the… 
1954
1954
Factors influencing the specificity of action of an antileukemic agent (aminopterin); time of treatment and dosage schedule.
Summary The antileukemic specificity of action of aminopterin, defined in terms of the relative effect of drug on host and tumor… 
1949
1949
Bone‐marrow changes in man after treatment with aminopterin, amethopterin, and aminoanfol. With special reference to megaloblastosis and tumor remission
L I T E R A T U R E on bone-marrow changes following administration of folic acid antagonists is scarce. In mice,l2 the…