Aminopterin

Known as: Aminopteroylglutamic Acid, N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}benzoyl)glutamic acid, 4-Amino-PGA 
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate… (More)
National Institutes of Health

Related topics

Related topics

35 relations

Narrower (23)

10-deazaaminopterin10-propargyl-10-deazaaminopterin10-propargylaminopterin11-oxahomoaminopterin
(More)
Aminopterin SodiumIn Bloodagonistsanalogs & derivatives
(More)

Broader (4)

Antineoplastic AgentsFolic Acid AntagonistsPesticidesPteridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Anticancer polymeric nanomedicine bearing synergistic drug combination
  • 2014
SUMMARY A novel polymer-based multi-drug nanosized conjugate was developed. We demonstrate here the advantage of a combined… (More)
  • figure 2
  • figure 1
Is this relevant?
2011
2011
A New Model Using Routinely Available Clinical Parameters to Predict Significant Liver Fibrosis in Chronic Hepatitis B
OBJECTIVE We developed a predictive model for significant fibrosis in chronic hepatitis B (CHB) based on routinely available… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
1999
Review
1999
Developmental delay in fetal aminopterin/methotrexate syndrome.
Maternal exposures to aminopterin and methotrexate have been associated with a pattern of malformation which includes prenatal… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels.
Editing of the non-protein amino acid homocysteine, a frequent type of error-correcting process in amino acid selection for… (More)
  • table I
  • figure 1
  • table II
  • table III
  • figure 2
Is this relevant?
1995
1995
Eimeria maxima gametocyte antigens: potential use in a subunit maternal vaccine against coccidiosis in chickens.
Affinity-purified gametocyte antigens (APGA) from Eimeria maxima, emulsified in Freund's adjuvant, were injected intramuscularly… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.
We have selected mutations in genes encoding components of the signaling pathway for alpha interferon (IFN-alpha) by using a… (More)
Is this relevant?
1984
1984
New folate analogs of the 10-deaza-aminopterin series
A group of folate analogs of the 10-deaza-aminopterin series, which were designed on the basis of the results of an intensive… (More)
  • figure 1
  • table 1
  • table 4
  • table 5
  • table 6
Is this relevant?
1984
1984
New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties
Structural modification of the N10 position of 4-amino folates affects mediated membrane transport in mammalian cells but has… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
1981
1981
A monoclonal antibody that recognizes B cells and B cell precursors in mice
The monoclonal antibody, RA3-2C2, appears to be specific for cells within the B cell lineage. This antibody does not recognize… (More)
  • table I
  • table II
  • table III
  • table V
  • table IV
Is this relevant?
1979
1979
Lipid composition of aminopterin-resistant and sensitive strains of Streptococcus pneumoniae. Effect of aminopterin inhibition.
The polar lipids of Streptococcus pneumoniae wild type and aminopterin-resistant strains were analysed. The membrane contained… (More)
Is this relevant?