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Aminopterin

Known as: Aminopteroylglutamic Acid, N-(4-{[(2,4-Diamino-6-pteridinyl)methyl]amino}benzoyl)glutamic acid, 4-Amino-PGA 
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate… Expand
National Institutes of Health

Related topics

Related topics

36 relations

Narrower (23)

10-deazaaminopterin10-propargyl-10-deazaaminopterin10-propargylaminopterin11-oxahomoaminopterin
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Aminopterin SodiumIn BloodNCIt Antineoplastic Agent Terminologyagonists
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Broader (4)

Antineoplastic AgentsFolic Acid AntagonistsPesticidesPteridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1992
Highly Cited
1992
Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons
We have developed a series of mouse‐mouse neural hybrid cell lines by fusing the aminopterin‐sensitive neuroblastoma N18TG2 with… Expand
Highly Cited
1989
Highly Cited
1989
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.
Generation of nitric oxide (NO.), an autacoid with vasorelaxant and cytotoxic properties, requires at least three cytosolic… Expand
Highly Cited
1981
Highly Cited
1981
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.
  • R. Mulligan, P. Berg
  • Proceedings of the National Academy of Sciences…
  • 1981
    • Corpus ID: 46717950
Cultured monkey (TC7) and mouse (3T6) cells synthesize an Excherichia coli enzyme, xanthine-guanine phosphoribosyltransferase… Expand
Review
1980
Review
1980
Production of monoclonal antibodies: strategy and tactics.
A myeloma line has been developed which produces no globulin chains of its own, has a duplication of 8.7 h, fuses effectively… Expand
Highly Cited
1979
Highly Cited
1979
Monoclonal antibody to a plasma membrane antigen of neurons.
Fusion of spleen cells from a mouse immunized with chicken embryo retina cells with clonal mouse myeloma cells yielded a… Expand
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Highly Cited
1975
Highly Cited
1975
Chemical induction of sperm abnormalities in mice.
The sperm of (C57BL X C3H)F1 mice were examined 1, 4, and 10 weeks after a subacute treatment with one of 25 chemicals at two or… Expand
Highly Cited
1974
Highly Cited
1974
A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors
Abstract A neuroblastoma × glioma hybrid cell line with well-developed neural properties was found that has high-affinity… Expand
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Highly Cited
1952
Highly Cited
1952
Therapeutic abortions with a folic acid antagonist, 4-aminopteroylglutamic acid (4-amino P.G.A) administered by the oral route.
  • J. B. Thiersch
  • American journal of obstetrics and gynecology
  • 1952
    • Corpus ID: 32085389
1. Oral doses of 6 to 12 mg. 4-amino P. G. A. induced fetal death in the first trimester of pregnancy followed by spontaneous… Expand
Highly Cited
1951
Highly Cited
1951
THERAPEUTIC SUPPRESSION OF TISSUE REACTIVITY: II. Effect of Aminopterin in Rheumatoid Arthritis and Psoriasis
Highly Cited
1948
Highly Cited
1948
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia… Expand
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