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10-propargyl-10-deazaaminopterin

Known as: (2S)-2-[[4-[(1RS)-1-[(2, 4-Diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic Acid, N-(4-{1-[(2,4-Diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic Acid, PDX 
National Institutes of Health

Papers overview

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Review
2014
Review
2014
The development of novel cancer therapeutics is often plagued by discrepancies between drug efficacies obtained in preclinical… Expand
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Review
2014
Review
2014
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key events in the development of glioma, acute myeloid leukemia… Expand
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Highly Cited
2012
Highly Cited
2012
The relative contribution of novel fibers such as polydextrose and soluble corn fiber (SCF) to the human gut microbiome and its… Expand
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Highly Cited
2009
Highly Cited
2009
Our study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation… Expand
Highly Cited
2006
Highly Cited
2006
Purpose: Methotrexate is known to synergize with cytarabine [1-β-d-arabinofuranosylcytosine (ara-C)] in a schedule-dependent… Expand
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Highly Cited
2003
Highly Cited
2003
PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor… Expand
Highly Cited
2000
Highly Cited
2000
The 10-deazaaminopterins are a new class of rationally designed antifolates demonstrating greater antitumor effects than… Expand
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Highly Cited
1999
Highly Cited
1999
ABSTRACT Homeobox (hox) proteins have been shown to regulate cell fate and segment identity by promoting the expression of… Expand
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Highly Cited
1999
Highly Cited
1999
I. FEMINIST CRITIQUES WITHIN THE DISCIPLINES "The Egg and the Sperm: How Science Has Constructed a Romance Based on Stereotypical… Expand
Highly Cited
1993
Highly Cited
1993
Successive alkylation of dimethyl homoterephthalate with propargyl bromide and 2,4-diamino-6-(bromomethyl)pteridine followed by… Expand