10-propargyl-10-deazaaminopterin

Known as: (2S)-2-[[4-[(1RS)-1-[(2, 4-Diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic Acid, N-(4-{1-[(2,4-Diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic Acid, PDX 
 

Topic mentions per year

Topic mentions per year

1993-2017
01219932017

Papers overview

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2017
2017
Manipulating gut microbes may improve mental health. Prebiotics are indigestible compounds that increase the growth and activity… (More)
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2010
2010
PURPOSE Pralatrexate (10-propargyl-10-deazaaminopterin) is an antifolate with improved cellular uptake and retention due to… (More)
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2009
2009
Our study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation… (More)
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2007
2007
BACKGROUND Several previous clinical trials have shown that malignant pleural mesothelioma is responsive to antifolates. The… (More)
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2003
2003
PURPOSE 10-propargyl-10-deazaaminopterin (PDX) has superior antitumor efficacy in mouse xenograft models, likely attributable to… (More)
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2003
2003
PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor… (More)
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2001
2001
Studies described here sought to evaluate the therapeutic potential of a new 10-deazaaminopterin analogue, 10-propargyl-10… (More)
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2000
2000
The 10-deazaaminopterins are a new class of rationally designed antifolates demonstrating greater antitumor effects than… (More)
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2000
2000
Earlier studies from this laboratory have shown that the uricosuric agent probenecid (PBCD) will inhibit the extrusion of folate… (More)
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1993
1993
Successive alkylation of dimethyl homoterephthalate with propargyl bromide and 2,4-diamino-6-(bromomethyl)pteridine followed by… (More)
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