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10-propargyl-10-deazaaminopterin

Known as: (2S)-2-[[4-[(1RS)-1-[(2, 4-Diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic Acid, N-(4-{1-[(2,4-Diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic Acid, PDX 
 
National Institutes of Health

Papers overview

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Review
2014
Review
2014
The development of novel cancer therapeutics is often plagued by discrepancies between drug efficacies obtained in preclinical… Expand
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Highly Cited
2012
Highly Cited
2012
The relative contribution of novel fibers such as polydextrose and soluble corn fiber (SCF) to the human gut microbiome and its… Expand
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Highly Cited
2009
Highly Cited
2009
Our study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation… Expand
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2007
2007
Background: Several previous clinical trials have shown that malignant pleural mesothelioma is responsive to antifolates. The… Expand
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Highly Cited
2003
Highly Cited
2003
PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor… Expand
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2003
2003
PURPOSE 10-propargyl-10-deazaaminopterin (PDX) has superior antitumor efficacy in mouse xenograft models, likely attributable to… Expand
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Highly Cited
2000
Highly Cited
2000
The 10-deazaaminopterins are a new class of rationally designed antifolates demonstrating greater antitumor effects than… Expand
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Highly Cited
1999
Highly Cited
1999
ABSTRACT Homeobox (hox) proteins have been shown to regulate cell fate and segment identity by promoting the expression of… Expand
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Highly Cited
1999
Highly Cited
1999
I. FEMINIST CRITIQUES WITHIN THE DISCIPLINES "The Egg and the Sperm: How Science Has Constructed a Romance Based on Stereotypical… Expand
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1993
1993
Successive alkylation of dimethyl homoterephthalate with propargyl bromide and 2,4-diamino-6-(bromomethyl)pteridine followed by… Expand
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