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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
  • M. Hentze, L. Kühn
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 6 August 1996
As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in biology and medicine. At the cellular level, the basic molecular framework for the regulation of ironExpand
LAT2, a New Basolateral 4F2hc/CD98-associated Amino Acid Transporter of Kidney and Intestine*
Glycoprotein-associated amino acid transporters (gpaAT) are permease-related proteins that require heterodimerization to express their function. So far, four vertebrate gpaATs have been shown toExpand
Amino acid transport of y+L‐type by heterodimers of 4F2hc/CD98 and members of the glycoprotein‐associated amino acid transporter family
Amino acid transport across cellular membranes is mediated by multiple transporters with overlapping specificities. We recently have identified the vertebrate proteins which mediate Na+‐independentExpand
Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor.
Iron regulatory factor (IRF) is a cytoplasmic mRNA-binding protein with specificity for iron-responsive element (IRE) RNA stem-loops. IRF post-transcriptionally regulates intracellular iron levelsExpand
Glycoprotein-associated amino acid exchangers: broadening the range of transport specificity
Abstract. Members of the newly discovered glycoprotein-associated amino acid transporter family (gpaAT-family) share a similar primary structure with >40% identity, a predicted 12-transmembraneExpand
Mutational analysis of the [4Fe‐4S]‐cluster converting iron regulatory factor from its RNA‐binding form to cytoplasmic aconitase.
The control of cellular iron homeostasis involves the coordinate post‐transcriptional regulation of ferritin mRNA translation and transferring receptor mRNA stability. These regulatory events areExpand
Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.
Biosynthesis of nitric oxide (NO) from L‐arginine modulates activity of iron‐dependent enzymes, including mitochondrial acontiase, an [Fe‐S] protein. We examined the effect of NO on the activity ofExpand
Iron Regulatory Proteins 1 and 2 Bind Distinct Sets of RNA Target Sequences (*)
Iron regulatory proteins (IRPs) 1 and 2 bind with equally high affinity to iron-responsive element (IRE) RNA stem-loops located in mRNA untranslated regions and, thereby, post-transcriptionallyExpand
Luminal heterodimeric amino acid transporter defective in cystinuria.
Mutations of the glycoprotein rBAT cause cystinuria type I, an autosomal recessive failure of dibasic amino acid transport (b(0,+) type) across luminal membranes of intestine and kidney cells. HereExpand
A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm
Expression of the human transferrin receptor (hTR) and its mRNA is strongly induced by iron deprivation. By measuring transcription elongation rates, levels of hTR-specific nuclear RNA, and mRNAExpand
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