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Am 580

Known as: AM-580, Am580 
National Institutes of Health

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4 relations

Broader (4)

Antineoplastic AgentsBenzoatesTeratogensTetrahydronaphthalenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors.
Highly Cited
2010
Highly Cited
2010
Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung
Vitamin A (VA) is essential for fetal lung development and postnatal lung maturation. VA is stored mainly as retinyl esters (REs… 
2006
2006
Retinoic Acid Exerts Dual Regulatory Actions on the Expression and Nuclear Localization of Interferon Regulatory Factor-1
Interferon regulatory factor-1 (IRF-1), a transcription factor and tumor suppressor involved in cell growth regulation and immune… 
2002
2002
Automated in vitro screening of teratogens.
We present a new in vitro assay for screening of potential teratogens, based on staining of cultured mouse fibroblastoid L929… 
2000
2000
Effect of receptor-selective retinoids on growth and differentiation pathways in mouse melanoma cells.
2000
2000
Critical role of the H6-H7 loop in the conformational adaptation of all-trans retinoic acid and synthetic retinoids within the ligand-binding site of RARalpha.
The pleiotropic effects of the natural and synthetic retinoids are mediated by the activation of the two subfamilies of nuclear… 
Highly Cited
1997
Highly Cited
1997
RARalpha-mediated teratogenicity in mice is potentiated by an RXR agonist and reduced by an RAR antagonist: dissection of retinoid receptor-induced pathways.
To dissect the complex pattern of retinoid-induced developmental defects, an RXR-selective agonist (AGN191701, an arylpropenyl… 
Highly Cited
1996
Highly Cited
1996
Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase.
All-trans retinoic acid (t-RA) administration leads to complete remission in acute promyelocytic leukemia (APL) patients by… 
Review
1996
Review
1996
Receptor-selective retinoid agonists and teratogenic activity.
Retinoid mechanism of action is dependent upon interaction with the retinoid nuclear RAR and RXR subfamilies of receptors. Study… 
1993
1993
Effects of synthetic retinoids and retinoic acid isomers on the expression of alkaline phosphatase in F9 teratocarcinoma cells.
Expression of ALP in F9 teratocarcinoma cells is induced by all-trans retinoic acid (ATRA) (Gianni' et al., Biochem. J. 274: 673… 
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