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Selective high affinity retinoic acid receptor alpha or beta-gamma ligands.
TLDR
Two complementary assays are set up, an in vitro binding assay to determine the Kd values of retinoids for RAR alpha, RAR beta, and RAR gamma and a functional assay in cultured cells to evaluate the potential of Retinoids to transactivate, through their binding to one type of RAR, a reporter gene. Expand
Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma.
TLDR
Using in vitro binding studies and a functional transactivation assay, this work has identified three compounds with high RAR gamma selectivity that could provide therapeutic entities with a higher therapeutic index at lower teratogenic risk. Expand
13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors.
TLDR
High levels of mRNA levels of cellular retinoic acid-binding protein II, which is supposed to regulate the concentration of intracellular all-trans retinoid acid, rapidly increased under all- trans retinoi acid treatment, whereas the 13-cis retinooic acid effect was markedly weaker and delayed. Expand
Retinoic acids regulate apoptosis of T lymphocytes through an interplay between RAR and RXR receptors
TLDR
It is demonstrated that retinoids can induce apoptosis of T cells through the stimulation of R ARγ, and a possible mechanism through which costimulation of RARs and RXRs might affect spontaneous and activation-induced death of T lymphocytes is proposed. Expand
Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway.
TLDR
A novel retinoid 6-[3-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN; CD437) is described that not only totally inhibits the proliferation of RA-resistant leukemic cell lines HL-60R and K562 but also induces apoptosis in these cells. Expand
Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway.
TLDR
It is reported that both all-trans and 9-cis retinoic acid induce apoptosis of mouse thymocytes and purified CD4+CD8+ cells in ex vivo cultures, with the latter being 50 times more effective than the former. Expand
Identification and Characterization of a Cell Cycle and Apoptosis Regulatory Protein-1 as a Novel Mediator of Apoptosis Signaling by Retinoid CD437*
TLDR
Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents. Expand
Retinoids are positive effectors of adipose cell differentiation
TLDR
It is shown that, when present at concentrations below or close to the Kd values of retinoic acid receptors, retinoids behave as potent adipogenic hormones (1 pM to 10 nM range) and, by the use of specific ligands for each RAR subtype, these positive effects on adipose differentiation involve in particular the RAR alpha subtype. Expand
Morphological and biochemical characterization of the cornified envelopes from human epidermal keratinocytes of different origin.
TLDR
No difference could be detected in the peptide maps of CEf and CEr obtained after tape stripping from the same healthy volunteer indicating that CE maturation within the stratum corneum does not involve the provision of qualitatively new proteins. Expand
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