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Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology.
TLDR
Current knowledge on the structure, enzymology, genetics, regulation and pathophysiology of mammalian molybdo-flavoenzymes is summarized. Expand
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
TLDR
An overview of the current knowledge of genetics, evolution, structure, enzymology, tissue distribution and regulation of mammalian aldehyde oxidases is provided. Expand
The role of aldehyde oxidase in drug metabolism
TLDR
There is evidence for an increasing relevance of AOX1 in the metabolism and clearance of new drugs, as measures aiming at controlling CYP450-dependent metabolism of prospective therapeutic agents are becoming routine. Expand
Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells.
TLDR
The data show that ATRA is capable of modulating the amounts and the state of activation of some of the components of the IFN intracellular signaling pathways, and suggest that the retinoid can bypass IFN/IFN-receptor interactions and induce the expression of IFN-regulated genes. Expand
The mammalian aldehyde oxidase gene family
TLDR
The present paper provides an update of the available information on the evolutionary history, tissue- and cell-specific distribution and function of mammalian aldehyde oxidases. Expand
The First Mammalian Aldehyde Oxidase Crystal Structure
TLDR
The mouse liver aldehyde oxidase 3 three-dimensional structure combined with kinetic, mutagenesis data, molecular docking, and molecular dynamics studies make a decisive contribution to understand the molecular basis of its rather broad substrate specificity. Expand
Induction of miR-21 by Retinoic Acid in Estrogen Receptor-positive Breast Carcinoma Cells
TLDR
It is found that pro-oncogenic miR-21 is selectively induced by ATRA in ERα+ cells, and three novel direct mi R-21 targets are identified: the pro-inflammatory cytokine IL1B, the adhesion molecule ICAM-1 and PLAT, the tissue-type plasminogen activator. Expand
Increasing recognition of the importance of aldehyde oxidase in drug development and discovery
TLDR
The potential offered by human aldehyde oxidase targeting for the development of new pharmacological agents is highlighted, limiting the authors' attention to the realms of antiobesity and anti-cancer drugs. Expand
The Impact of Single Nucleotide Polymorphisms on Human Aldehyde Oxidase
TLDR
The human population is characterized by the presence of functionally inactive hAOX1 allelic variants as well as variants encoding enzymes with different catalytic activities, which should be considered for the design of future drugs. Expand
Regulation and Biochemistry of Mouse Molybdo-flavoenzymes
TLDR
It is demonstrated that CD-1, C57BL/6, 129/Sv, and other mouse strains synthesize high levels of AOH1 in the liver and AOH2 in the skin, and that neither enzyme is involved in the in vivo biotransformation of acetaldehyde. Expand
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