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Actinomycin

Known as: Actinomycin Antineoplastic Antibiotic, Actinomycines, Actinomycins 
A chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin antibiotics inhibit DNA replication and RNA and… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute one of the main reasons of deaths… Expand
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Highly Cited
1990
Highly Cited
1990
We have characterized the normal human tissue distribution and tumor expression of the human multidrug resistance gene (MDR1… Expand
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Highly Cited
1986
Highly Cited
1986
Human recombinant tumor necrosis factor (rTNF) was found to act directly on cultured human vascular endothelium to induce a… Expand
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Highly Cited
1985
Highly Cited
1985
  • H. Sobell
  • Proceedings of the National Academy of Sciences…
  • 1985
  • Corpus ID: 18010375
Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a… Expand
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Highly Cited
1985
Highly Cited
1985
Increased leukocyte adhesion to the endothelial lining of blood vessels is an essential event in inflammation and the… Expand
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Highly Cited
1984
Highly Cited
1984
Dexamethasone and corticosterone kill mouse thymocytes, as measured by eosin uptake, after several hours of in vitro incubation… Expand
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Highly Cited
1976
Highly Cited
1976
125I-labeled human epidermal growth factor (hEGF) binds in a specific and saturable manner to human fibroblasts. At 37 degrees C… Expand
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Highly Cited
1969
Highly Cited
1969
1. Experiments to determine the point of commitment to sporulation were carried out by restoring nutrients at different times to… Expand
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Highly Cited
1968
Highly Cited
1968
Equilibrium, kinetic and hydrodynamic studies are reported of the binding to DNA of actinomycin, its derivatives, and some… Expand
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Highly Cited
1967
Highly Cited
1967
Abstract At high salt concentrations, ethidium bromide (EB) is shown to form a fluorescent complex with helical polynucleotides… Expand
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