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Actinomycin

Known as: Actinomycin Antineoplastic Antibiotic, Actinomycines, Actinomycins 
A chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin antibiotics inhibit DNA replication and RNA and… 
National Institutes of Health

Related topics

Related topics

7 relations
Actinomycin [EPC]Cosmegen

Broader (3)

Antibiotics, AntineoplasticCyclic PeptidesDepsipeptides

Narrower (2)

Dactinomycincactinomycin

Papers overview

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1986
1986
Footprinting reveals that nogalamycin and actinomycin shuffle between DNA binding sites.
The hypothesis that sequence-selective DNA-binding antibiotics locate their preferred binding sites by a process involving… 
1981
1981
Mutual interaction between adjacent dG . dC actinomycin binding sites and dA . dT netropsin binding sites on the self-complementary d(C-G-C-G-A-A-T-T-C-G-C-G) duplex in solution.
The Watson-Crick imino protons, the backbone phosphodiester resonances, and the antibiotic exchangeable protons have been used as… 
Highly Cited
1976
Highly Cited
1976
Priming effect of luteinizing hormone releasing factor: in-vitro and in-vivo evidence consistent with its dependence upon protein and RNA synthesis.
The aim of this study was to determine whether the priming effect of LH-RF depends upon RNA and protein synthesis. In in-vivo… 
Review
1975
Review
1975
Three-dimensional structure of the actinomycins.
  • H. Lackner
  • Angewandte Chemie
  • 1975
  • Corpus ID: 31585019
Many complicated three-dimensional structures can be formulated for the actinomycins, red chromopeptide antibiotics distinguished… 
1974
1974
Inhibition of acquired resistance to tobacco mosaic virus by actinomycin D.
Summary In tobacco (Nicotiana tabacum cv. Xanthi-nc) actinomycin D inhibits the resistance to tobacco mosaic virus that is… 
1970
1970
Sequential morphological alterations in hepatic cell nucleoli induced by varying doses of actinomycin D.
White female rats were given injections i.v. or i.p. of actinomycin D and the sequence of nucleolar segregation or reorganization… 
Highly Cited
1967
Highly Cited
1967
The interaction of actinomycin with DNA: requirement for the 2-amino group of purines.
The formation of complexes between actinomycin (AM) (Fig. 1) and DNA is known to depend on specific structures in both the… 
Highly Cited
1964
Highly Cited
1964
STUDIES ON THE MECHANISM OF DIETHYLSTILBESTROL-INDUCED FORMATION OF PHOSPHOPROTEIN IN MALE CHICKENS.
The blood of laying contains a phosphoprotein fraction that is absent from the blood of nonlaying cockerels This material, like… 
Highly Cited
1964
Highly Cited
1964
ROLE OF ENZYMES IN HOMEOSTASIS. V. ACTINOMYCIN AND PUROMYCIN INHIBITION OF CORTISONE-INDUCED SYNTHESIS OF HEPATIC GLUCOSE 6-PHOSPHATASE AND FRUCTOSE 1,6-DIPHOSPHATASE.
A basic requirement in maintaining t,he homeostatic dynamic equilibrium in the mammalian organism is the ability to alter the… 
1963
1963
PREVENTION OF HORMONE ACTION BY LOCAL APPLICATION OF ACTINOMYCIN D.
Previous work in this laboratory has suggested that growth hormone may exert its anabolic effect on liver by initial activation…