Actinomycin

Known as: Actinomycin Antineoplastic Antibiotic, Actinomycines, Actinomycins 
A chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin antibiotics inhibit DNA replication and RNA and… (More)
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
The oncoprotein MDM2 associates with ribosomal proteins L5, L11, and L23. Both L11 and L23 have been shown to activate p53 by… (More)
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Highly Cited
2001
Highly Cited
2001
Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking… (More)
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Highly Cited
2001
Highly Cited
2001
The human positive transcription elongation factor P-TEFb, consisting of a CDK9/cyclin T1 heterodimer, functions as both a… (More)
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Highly Cited
1999
Highly Cited
1999
Estrogen is an important vasoprotective molecule that causes the rapid dilation of blood vessels by activating endothelial nitric… (More)
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Highly Cited
1990
Highly Cited
1990
We have characterized the normal human tissue distribution and tumor expression of the human multidrug resistance gene (MDR1… (More)
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Highly Cited
1986
Highly Cited
1986
Human recombinant tumor necrosis factor (rTNF) was found to act directly on cultured human vascular endothelium to induce a… (More)
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Highly Cited
1985
Highly Cited
1985
  • H M Sobell
  • Proceedings of the National Academy of Sciences…
  • 1985
Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a… (More)
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Highly Cited
1984
Highly Cited
1984
Dexamethasone and corticosterone kill mouse thymocytes, as measured by eosin uptake, after several hours of in vitro incubation… (More)
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Highly Cited
1984
Highly Cited
1984
Preincubation of tumor cells with actinomycin D (Act D) rendered various murine and human lines susceptible to killing by… (More)
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Highly Cited
1969
Highly Cited
1969
1. Experiments to determine the point of commitment to sporulation were carried out by restoring nutrients at different times to… (More)
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