cactinomycin

Known as: Actinomycin C 
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces chrysomallus. Cactinomycin binds to DNA by intercalating between… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
05101519522016

Papers overview

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Highly Cited
2000
Highly Cited
2000
BACKGROUND The DNA replication checkpoint ensures that mitosis is not initiated before DNA synthesis is completed. Recent studies… (More)
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Highly Cited
1996
Highly Cited
1996
The detection and quantitation of apoptotic cells is becoming increasingly important in the investigation of the role of… (More)
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1996
1996
DNA topoisomerase I is the cytotoxic target for chemotherapeutic agents of the camptothecin class. The cytotoxicity of these… (More)
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1995
1995
We assessed the role of cyclic nucleotides in modulating lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-alpha… (More)
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Highly Cited
1993
Highly Cited
1993
IL-1 is a pro-inflammatory cytokine which controls many features of the immune and inflammatory response. When injected into a… (More)
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Highly Cited
1984
Highly Cited
1984
Friend leukemia cells from exponentially growing or differentiated (DMSO-induced) cultures were permeabilized and their DNA was… (More)
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1983
1983
Glycoproteins and gangliosides of spontaneously trans formed Chinese hamster lung cells (DC-3F) and of vincristineand… (More)
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1983
1983
The effects of the anticancer drugs 4'-demethylepipodophyllotoxin thenylidene /3-o-glucoside and 4'-demethylepipodophyllotoxin… (More)
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1981
1981
Previous work has shown that exposing mouse L1210 cells to intercalating agents such as adriamycin, ellipticine and actinomycin D… (More)
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