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Dactinomycin

Known as: 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3, AD, Actinomycin I1 
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA… 
National Institutes of Health

Related topics

Related topics

43 relations
AcFuCy protocolChoriocarcinomaEMA-CO RegimenIn Blood

Broader (1)

Antibiotics, Antineoplastic

Narrower (18)

BCD protocolCosmegenDD1 protocolFDV protocol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1983
Highly Cited
1983
Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.
The effects of the anticancer drugs 4′-demethylepipodophyllotoxin thenylidene β-d-glucoside and 4′-demethylepipodophyllotoxin… 
Highly Cited
1983
Highly Cited
1983
Antitumor effect of actinomycin D entrapped in liposomes bearing subunits of tumor-specific monoclonal immunoglobulin M antibody.
Sonicated liposomes containing actinomycin D in the membranes were chemically coated with the subunits of monoclonal… 
Highly Cited
1978
Highly Cited
1978
The maturation of rabbit epididymal spermatozoa in organ culture: inhibition by antiandrogens and inhibitors of ribonucleic acid and protein synthesis.
Infertile spermatozoa from the proximal corpus epididymidis will become fertile when this epididymal segment is cultured 24 h in… 
Highly Cited
1977
Highly Cited
1977
Decreased retention of actinomycin D as the basis for cross-resistance in anthracycline-resistant sublines of P388 leukemia.
Sublines of P388 leukemia resistant to Adriamycin and daunorubicin were cross-resistant to actinomycin D in vivo and in vitro… 
Highly Cited
1976
Highly Cited
1976
Priming effect of luteinizing hormone releasing factor: in-vitro and in-vivo evidence consistent with its dependence upon protein and RNA synthesis.
The aim of this study was to determine whether the priming effect of LH-RF depends upon RNA and protein synthesis. In in-vivo… 
Highly Cited
1971
Highly Cited
1971
Effect of protein and insulin on linoleic acid desaturation of normal and diabetic rats.
The effect of glucose, protein or lipid diet and insulin treatment on the desaturation of linoleic to -y-linolenic acid by liver… 
Highly Cited
1967
Highly Cited
1967
Nature of the inactivating action of trypsin on foot-and-mouth disease virus.
The infectivity of suspensions of foot-and-mouth disease virus is greatly reduced by incubation with trypsin. Preliminary studies… 
Highly Cited
1963
Highly Cited
1963
THE ROLE OF RNA SYNTHESIS IN EARLY ESTROGEN ACTION.
Previous studies from this laboratory have demonstrated that in the rat uterus the early response to estradiol is characterized… 
Highly Cited
1963
Highly Cited
1963
Effects of Actinomycin D on Morphogenesis
THE possible role in morphogenesis of ribonucleic acids (RNA) produced by the cell nuclei (presumably ‘messenger’ RNA's) has been… 
Highly Cited
1963
Highly Cited
1963
Action of Insulin on the Isolated Rat Diaphragm in the Presence of Actinomycin D and Puromycin
WITHIN recent years, conclusive evidence has been obtained of a direct stimulation of transport of sugar from the extracellular… 
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