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Dactinomycin

Known as: 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3, AD, Actinomycin I1 
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA… 
National Institutes of Health

Related topics

Related topics

43 relations
AcFuCy protocolChoriocarcinomaEMA-CO RegimenIn Blood

Broader (1)

Antibiotics, Antineoplastic

Narrower (18)

BCD protocolCosmegenDD1 protocolFDV protocol

Papers overview

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Highly Cited
1983
Highly Cited
1983
Antitumor effect of actinomycin D entrapped in liposomes bearing subunits of tumor-specific monoclonal immunoglobulin M antibody.
Sonicated liposomes containing actinomycin D in the membranes were chemically coated with the subunits of monoclonal… 
Highly Cited
1976
Highly Cited
1976
Priming effect of luteinizing hormone releasing factor: in-vitro and in-vivo evidence consistent with its dependence upon protein and RNA synthesis.
The aim of this study was to determine whether the priming effect of LH-RF depends upon RNA and protein synthesis. In in-vivo… 
Highly Cited
1976
Highly Cited
1976
Qualitative patterns of protein synthesis in the mouse oocyte.
Mouse oocytes were found to synthesize proteins actively at the germinal vesicle, metaphase I, metaphase II, and pronuclear (6… 
Highly Cited
1975
Highly Cited
1975
Studies on lipopolysaccharides isolated from strains of Neisseria gonorrhoeae.
Lipopolysaccharides, extracted by phenol-water from five strains fo Neisseria gonorrhoeae, were purified by treatment with… 
Highly Cited
1971
Highly Cited
1971
Effect of protein and insulin on linoleic acid desaturation of normal and diabetic rats.
The effect of glucose, protein or lipid diet and insulin treatment on the desaturation of linoleic to -y-linolenic acid by liver… 
Highly Cited
1967
Highly Cited
1967
Nature of the inactivating action of trypsin on foot-and-mouth disease virus.
The infectivity of suspensions of foot-and-mouth disease virus is greatly reduced by incubation with trypsin. Preliminary studies… 
Highly Cited
1965
Highly Cited
1965
ACTINOMYCIN D. EFFECTS ON NUCLEIC ACID AND PROTEIN METABOLISM IN INTACT AND REGENERATING LIVER OF RATS.
Single, lethal doses of actinomycin D (1 mg/kg) promptly decreased the rate of incorporation of C14-orotate into nuclear… 
Highly Cited
1965
Highly Cited
1965
EXTRACELLULAR RIBONUCLEASE FORMATION IN BACILLUS SUBTILIS AND ITS STIMULATION BY ACTINOMYCIN D.
1. Extracellular ribonuclease is produced linearly for at least 3hr. by washed post-logarithmic-phase cells of Bacillus subtilis… 
Highly Cited
1963
Highly Cited
1963
Action of Insulin on the Isolated Rat Diaphragm in the Presence of Actinomycin D and Puromycin
WITHIN recent years, conclusive evidence has been obtained of a direct stimulation of transport of sugar from the extracellular… 
Highly Cited
1961
Highly Cited
1961
Possible role of potentiators in radiation therapy.
In retinoblastoma a higher cure rate with less damage to the adjacent normal tissue was demonstrated when TEM was used in…