Dactinomycin

Known as: 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3, AD, Actinomycin I1 
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
010020019512017

Papers overview

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Highly Cited
2003
Highly Cited
2003
BACKGROUND Ewing's sarcoma and primitive neuroectodermal tumor of bone are closely related, highly malignant tumors of children… (More)
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Highly Cited
2001
Highly Cited
2001
The human positive transcription elongation factor P-TEFb, consisting of a CDK9/cyclin T1 heterodimer, functions as both a… (More)
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Highly Cited
2000
Highly Cited
2000
TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine… (More)
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Highly Cited
1995
Highly Cited
1995
Shear stress enhances expression of Ca(2+)-calmodulin-sensitive endothelial cell nitric oxide synthase (ecNOS) mRNA and protein… (More)
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Highly Cited
1993
Highly Cited
1993
Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but… (More)
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Highly Cited
1990
Highly Cited
1990
We have characterized the normal human tissue distribution and tumor expression of the human multidrug resistance gene (MDR1… (More)
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Highly Cited
1986
Highly Cited
1986
By limiting dilution of WEHI 164 mouse fibrosarcoma cells we have isolated a cell line, WEHI 164 clone 13, which is extremely… (More)
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Highly Cited
1986
Highly Cited
1986
Human recombinant tumor necrosis factor (rTNF) was found to act directly on cultured human vascular endothelium to induce a… (More)
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Highly Cited
1984
Highly Cited
1984
Dexamethasone and corticosterone kill mouse thymocytes, as measured by eosin uptake, after several hours of in vitro incubation… (More)
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Highly Cited
1976
Highly Cited
1976
Two DNA binding guanine-specific antibiotics, chromomycin A3 (CMA) and the closely related mithramycin (MM), were used as… (More)
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