F. Brown

Publications353
h-index54
Citations12,034
Highly Influential Citations311
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The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution
The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other… Expand
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The Family Rhabdoviridae
The occurrence of rhabdoviruses in vertebrate, invertebrate, and plant hosts makes them a subject of interest not only to animal and plant virologists, but also to those interested in comparative… Expand
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The cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid).
The amino acid sequence RGD (arginine-glycine-aspartic acid) is highly conserved in the VP1 protein of foot-and-mouth disease virus (FMDV), despite being situated in the immunodominant hypervariable… Expand
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Myristylation of picornavirus capsid protein VP4 and its structural significance
We have obtained evidence that poliovirus and other picornavirus particles are specifically modified by having myristic acid covalently bound to a capsid protein. The electron density map… Expand
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Effective synthetic peptide vaccine for foot-and-mouth disease in swine.
We have designed a peptide-based vaccine for foot-and-mouth disease (FMD) effective in swine. The peptide immunogen has a G-H loop domain from the VP1 capsid protein of foot-and-mouth disease virus… Expand
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Presence of a covalently linked protein on calicivirus RNA.
The infective RNA of the calicivirus, vesicular exanthema virus, has been shown to contain a protein which is apparently linked to the RNA by a covalent bond. The protein remained bound to the RNA… Expand
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Epitope mapping of foot-and-mouth disease virus with neutralizing monoclonal antibodies.
Epitopes of strain A22 Iraq 24/64 of foot-and-mouth disease virus have been mapped with monoclonal antibodies (MAbs). Three methods were used: (i) an indirect ELISA using an overlapping set of… Expand
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Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein
Synthetic vaccines for viral diseases can use defined regions of viral proteins as immunogens1,2: the peptide sequence of amino acids 141–160 of the VP1 protein of foot and mouth disease virus (FMDV)… Expand
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Assignment of the genome segments of bluetongue virus type 1 to the proteins which they encode.
The purified genomic dsRNA of bluetongue virus type 1 (BTV 1) was separated into 10 size classes by polyacrylamide gel electrophoresis. These genome segments were recovered individually from the gel,… Expand
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Antigenic Differences between Isolates of Swine Vesicular Disease Virus and their Relationship to Coxsackie B5 Virus
THERE have been several outbreaks of a vesicular disease in swine in which the causative agent was shown to be an enterovirus1–3. The first occurred in Italy in 19661 and this was followed by an… Expand
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