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Acotiamide Hydrochloride

Known as: YM443 
The hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by… 
National Institutes of Health

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Z 338

Papers overview

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2018
2018
Real-World, Non-Interventional, Observational Study to Evaluate Effectiveness and Tolerability of Acotiamide Hydrochloride Hydrate in Treatment of Functional Dyspepsia
IntroductionFunctional dyspepsia (FD) is a highly prevalent condition which reduces patients’ quality of life (QoL) and imparts a… 
2017
2017
A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia
BackgroundAcotiamide is widely used to improve symptoms in patients with functional dyspepsia (FD) in multiple large-scale… 
2017
2017
In vivo metabolite identification of acotiamide in rats using ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry.
Acotiamide hydrochloride (ACT) is a drug used for the treatment of functional dyspepsia. Understanding which metabolites are… 
2015
2015
Novel Prokinetic Acotiamide Reduces Transient Lower Esophageal Sphincter Relaxation in Healthy Subjects
Background/Aims: Currently, there is no study evaluating the effect of acotiamide on transient lower esophageal sphincter… 
Review
2012
Review
2012
Acotiamide, a novel gastroprokinetic for the treatment of patients with functional dyspepsia: postprandial distress syndrome
Functional dyspepsia (FD) is a highly prevalent condition with major socioeconomic and healthcare impact. To date, no… 
2012
2012
Targeting cathepsins: a new glimmer of hope for pancreatic cancer therapy?
Recent whole-genome sequencing efforts have facilitated the detailed characterisation of the human degradome consisting of almost… 
Review
2011
Review
2011
Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia
Introduction: Functional dyspepsia (FD) is a highly prevalent condition with a major impact on quality of life and high socio… 
Highly Cited
2011
Highly Cited
2011
Acotiamide Hydrochloride (Z-338), a New Selective Acetylcholinesterase Inhibitor, Enhances Gastric Motility without Prolonging QT Interval in Dogs: Comparison with Cisapride, Itopride, and Mosapride
Acotiamide hydrochloride (acotiamide; N-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4… 
Highly Cited
2011
Highly Cited
2011
Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats.
Highly Cited
2010
Highly Cited
2010
Clinical trial: dose‐dependent therapeutic efficacy of acotiamide hydrochloride (Z‐338) in patients with functional dyspepsia – 100 mg t.i.d. is an optimal dosage
Background  Acotiamide is a selective acetylcholinesterase inhibitor and enhances the actions of cholinergic neurons localized in… 
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